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Eukaryotic translation initiation factor 4E nuclear import factor 1

4E-T, eIF4E-transporter
The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] (from NCBI)
Top mentioned proteins: eIF4E, V1a, caspase-3, CAN, ACID
Papers on 4E-T
A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis.
Miller et al., Toronto, Canada. In J Neurosci, Dec 2015
We identify, in embryonic neural precursors of the murine cortex, a Smaug2 protein/nanos1 mRNA complex that is present in cytoplasmic granules with the translational repression proteins Dcp1 and 4E-T.
Structure of a Human 4E-T/DDX6/CNOT1 Complex Reveals the Different Interplay of DDX6-Binding Proteins with the CCR4-NOT Complex.
Conti et al., München, Germany. In Cell Rep, Nov 2015
DDX6 interacts with the CCR4-NOT complex and functions in concert with several post-transcriptional regulators, including Edc3, Pat1, and 4E-T.
P-body assembly requires DDX6 repression complexes rather than decay or Ataxin2/2L complexes.
Weil et al., Paris, France. In Mol Biol Cell, Aug 2015
Three proteins were required in all tested conditions: DDX6, 4E-T, and LSM14A.
Xenopus CAF1 requires NOT1-mediated interaction with 4E-T to repress translation in vivo.
Wickens et al., Madison, United States. In Rna, Jul 2015
Our data reveal a chain of interacting proteins that links CAF1 to CCR4-NOT and to Xp54 and 4E-T.
The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5' and 3' Termini of Target mRNAs.
Fabian et al., Montréal, Canada. In Cell Rep, Jul 2015
Human 4E-T is an eIF4E-binding protein that has been reported to promote mRNA decay, albeit via an unknown mechanism.
Molecular architecture of 4E-BP translational inhibitors bound to eIF4E.
Izaurralde et al., Tübingen, Germany. In Mol Cell, Apr 2015
Here, we present structures of human eIF4E bound to 4E-BP1 and fly eIF4E bound to Thor, 4E-T, and eIF4G.
Distinct features of cap binding by eIF4E1b proteins.
Zuberek et al., Warsaw, Poland. In J Mol Biol, Mar 2015
eIF4E1b exhibited only very weak interactions with m(7)GTP-Sepharose and, rather than binding eIF4G, interacted with 4E-T.
High enantiomeric excess of the flavor relevant 4-alkyl-branched Fatty acids in milk fat and subcutaneous adipose tissue of sheep and goat.
Vetter et al., Stuttgart, Germany. In J Agric Food Chem, Feb 2015
In this study, we used enantioselective gas chromatography to study the enantiomeric composition of 4-methyloctanoic acid (4-Me-8:0) and 4-ethyloctanoic acid (4-Et-8:0) in milk and dairy products from sheep and goat as well as in goat subcutaneous tissue.
Dinuclear nickel(II) complexes with 2,5-diamino-1,4-benzoquinonediimine ligands as precatalysts for the polymerization of styrene: electronic and steric substituent effects.
Fujihara et al., Saitama, Japan. In Dalton Trans, Feb 2015
Catalytic polymerization of styrene with a series of dinuclear nickel(II) complexes [{Ni(acac)}2{μ-C6H2-(N-Ph-R)4}] (R = 4-Et (1a), 4-OEt (1b), 2-OEt (1c), 2-Et (1d), and 2,6-Et2 (1e)) in the presence of methylaluminoxane was studied under various conditions to evaluate the substituent effect.
ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis.
Hla et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2015
We show here that the RBP embryonic lethal abnormal vision like 1 (ELAVL1, also know as HuR) regulates the alternative splicing of eukaryotic translation initiation factor 4E nuclear import factor 1 (Eif4enif1), which encodes an eukaryotic translation initiation factor 4E transporter (4E-T) protein and suppresses the expression of capped mRNAs.
Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches.
Ramón Y Cajal et al., Barcelona, Spain. In Plos One, 2014
De novo accumulation of eIF4E-containing cytoplasmic bodies colocalizing with the eIF4E-binding protein 4E-T was observed after expression of phosphomimetic S209D, but not S209A or wild-type eIF4E.
An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program.
Miller et al., Toronto, Canada. In Neuron, 2014
We identify in neural precursors a repressive complex involving eIF4E1 and its binding partner 4E-T that coordinately represses translation of proteins that determine neurogenesis.
Concentrations of volatile 4-alkyl-branched fatty acids in sheep and goat milk and dairy products.
Vetter et al., Stuttgart, Germany. In J Food Sci, 2014
Goat milk and cheese resulted in higher concentrations for both fatty acids (190 to 480 μg/g milk fat) and smaller 4-Me-8:0 to 4-Et-8:0 ratios (1.4 to 2.7) compared to sheep milk and cheese (78 to 220 μg/g milk fat; 4-Me-8:0 to 4-Et-8:0 ratio: 15 to 42).
eIF4E-binding proteins: new factors, new locations, new roles.
Standart et al., Cambridge, United Kingdom. In Biochem Soc Trans, 2014
In the present article, we focus on the metazoan 4E-T (4E-transporter)/Cup family of eIF4E-binding proteins, and also discuss very recent examples in yeast, fruitflies and humans, some of which predictably inhibit translation, while others may result in mRNA decay or even enhance translation; altogether considerably expanding our understanding of the roles of eIF4E-binding proteins in gene expression regulation.
Post-transcriptional and post-translational regulation during mouse oocyte maturation.
Han et al., South Korea. In Bmb Rep, 2011
Many proteins, such as CPEB, maskin, eIF4E, eIF4G, 4E-BP, and 4E-T, post-transcriptionally regulate mRNA via binding to the cap structure at the 5' end of mRNA or its 3' untranslated region (UTR) to generate a closed-loop structure.
The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G.
Minami et al., Tokyo, Japan. In J Biol Chem, 2010
Hsp90 probably contributes to the correct localization of eIF4E and 4E-T to stress granules and also to the interaction between eIF4E and eIF4G, both of which may be needed for eIF4E to acquire the physiological functionality
Ectopic expression of eIF4E-transporter triggers the movement of eIF4E into P-bodies, inhibiting steady-state translation but not the pioneer round of translation.
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2008
Overexpression of eIF4E-T triggers the movement of eIF4E into the processing bodies.
A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay.
Sonenberg et al., Montréal, Canada. In J Cell Biol, 2005
A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay is described.
A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies.
Lührmann et al., Göttingen, Germany. In Rna, 2005
human P bodies contain the cap-binding protein eIF4E and the related factor eIF4E-transporter (eIF4E-T), suggesting novel roles for these proteins in targeting mRNAs for 5' --> 3' degradation
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