ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis.
New Haven, United States. In Proc Natl Acad Sci U S A, 2015
We show here that the RBP embryonic lethal abnormal vision like 1 (ELAVL1, also know as HuR) regulates the alternative splicing of eukaryotic translation initiation factor 4E nuclear import factor 1 (Eif4enif1), which encodes an eukaryotic translation initiation factor 4E transporter (4E-T) protein and suppresses the expression of capped mRNAs.
eIF4E-binding proteins: new factors, new locations, new roles.
Cambridge, United Kingdom. In Biochem Soc Trans, 2014
In the present article, we focus on the metazoan 4E-T (4E-transporter)/Cup family of eIF4E-binding proteins, and also discuss very recent examples in yeast, fruitflies and humans, some of which predictably inhibit translation, while others may result in mRNA decay or even enhance translation; altogether considerably expanding our understanding of the roles of eIF4E-binding proteins in gene expression regulation.