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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Eukaryotic translation initiation factor 3, subunit E

48-kDa, Int6, eIF3e
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, fibrillin-1, SDSL
Papers using 48-kDa antibodies
Multiple functions of Jab1 are required for early embryonic development and growth potential in mice
Smith Gilbert H et al., In Breast cancer research : BCR, 2003
... Int6 functional domains and wapint6sh transgenic construct ...
Papers on 48-kDa
Decreased eIF3e Expression Can Mediate Epithelial-to-Mesenchymal Transition through Activation of the TGFβ Signaling Pathway.
Lewis et al., Moncton, Canada. In Mol Cancer Res, Oct 2015
UNLABELLED: The eIF3e protein is a component of the multisubunit eIF3 complex, which is essential for cap-dependent translation initiation.
Purification and characterization of an extracellular uricase from a new isolate of Sphingobacterium thalpophilum (VITPCB5).
Jayaprakash et al., Vellore, India. In Protein Expr Purif, Oct 2015
The in-gel trypsin digested peptides of 48-kDa uricase when analyzed using mass spectrometry, gave 32% sequence coverage with the uricase (30-kDa) from Cyberlindnera jadinii.
Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness.
Liu et al., Houston, United States. In Oncogene, Oct 2015
Recurrent, gain-of-expression gene fusions of RSPO2 (to EIF3E) and RSPO3 (to PTPRK) occur in a subset of human colorectal cancer.
Nonantibestrophin Anti-RPE Antibodies in Paraneoplastic Exudative Polymorphous Vitelliform Maculopathy.
Marmorstein et al., Rochester, United States. In Transl Vis Sci Technol, May 2015
CONCLUSIONS: To our knowledge, this is the first report of PEPVM with an autoantibody to an approximately 48-kDa RPE protein, but previous reports have demonstrated autoantibodies to other RPE proteins, suggesting that autoantibody formation is an important component of PEPVM.
[Cloning, expression of gene SjOST48 from Schistosoma japonicum and evaluation of the immunoprotective efficacy of rSjOST48 in mice].
Lin et al., In Sheng Wu Gong Cheng Xue Bao, Apr 2015
Sequence analysis revealed that SJCHGC01743 was a 48-kDa subunit of the oligosaccharyltransferase complex (OST48) and named as SjOST48.
Silencing of eIF3e promotes blood perfusion recovery after limb ischemia through stabilization of hypoxia-inducible factor 2α activity.
Watanabe et al., Tokyo, Japan. In J Vasc Surg, Apr 2015
OBJECTIVE: We previously observed that silencing of eukaryotic translation initiation factor 3 subunit e (eIF3e), a hypoxia-independent downregulator of hypoxia-inducible factor 2α (HIF-2α), led to neoangiogenesis by promoting HIF-2α activity under normoxic conditions.
Significance of 40-, 45-, and 48-kDa Proteins in the Moderate-to-Severe Clinical Symptoms of Buckwheat Allergy.
Han et al., Seoul, South Korea. In Allergy Asthma Immunol Res, 2015
PURPOSE: This study was aimed to investigate the relationship between the allergen components and moderate-to-severe allergic reactions in patients with buckwheat allergy.
Hypoxia-inducible factor as an angiogenic master switch.
Shibasaki et al., New Haven, United States. In Front Pediatr, 2014
Eukaryotic initiation factor 3 subunit e (eIF3e)/INT6 interacts specifically with HIF-2α and induces the proteasome inhibitor-sensitive degradation of HIF-2α, independent of hypoxia and von Hippel-Lindau protein.
Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells.
Chang et al., Houston, United States. In Cell Biosci, 2014
BACKGROUND: The INT6 gene was first discovered as a site of integration in mouse mammary tumors by the mouse mammary tumor virus; however, INT6's role in the development of human breast cancer remains largely unknown.
[Frequency of diseases caused by group A streptococci among invasive infections of soft tissues and characteristics of the causative agent].
Lipatov et al., In Zh Mikrobiol Epidemiol Immunobiol, 2014
GAS emm-type was determined by molecular-genetic methods, as well as the presence of bacteriophage integrases int2, int3, int4, int5, int6, int7, int49, bacteriophage toxins speA, speI, sla, speC/J, speL, speH, speC, ssa and speB gene present on the chromosomal DNA.
Overexpression of eIF3e is correlated with colon tumor development and poor prognosis.
Fan et al., Jinan, China. In Int J Clin Exp Pathol, 2013
EIF3e is a component of the eukaryotic translation initiation factor 3 (eIF-3) complexes, which is an essential factor for initiation of protein synthesis in mammalian cells.
Galantamine for vascular cognitive impairment.
Craig et al., Oxford, United Kingdom. In Cochrane Database Syst Rev, 2012
Both trials had an overall low risk of bias.The GAL-INT-6 trial included 592 patients with vascular dementia diagnosed according to recognised criteria and patients with Alzheimer's disease and coincidental radiographic findings of cerebrovascular disease.
The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1.
Jalinot et al., Lyon, France. In J Virol, 2012
HTLV-1Tax binds both INT6 and UPF1. The analysis of Tax mutants indicated that the Tax-INT6 association is necessary for nonsense-mediated mRNA decay inhibition, and data suggest that Tax sequesters INT6 out of reach from UPF1.
INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation.
Jalinot et al., Lyon, France. In Rna, 2012
INT6 and MIF4GD were observed to colocalize in cytoplasmic foci. It was concluded that INT6, by establishing interactions with MIF4GD and SLBP, plays an important role in translation of poly(A) minus histone mRNAs.
INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells.
Jalinot et al., Lyon, France. In Cancer Res, 2012
findings reveal unexpected and striking connections of INT6 with ATM and BRCA1
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Expression of truncated eukaryotic initiation factor 3e (eIF3e) resulting from integration of mouse mammary tumor virus (MMTV) causes a shift from cap-dependent to cap-independent translation.
Rhoads et al., Shreveport, United States. In J Biol Chem, 2011
expression of 3e5 diminishes eIF4G interaction with eIF3 and causes abnormal gene expression at the translational level.
Clinical and laboratory aspects of Ro/SSA-52 autoantibodies.
Puttini et al., Milano, Italy. In Autoimmun Rev, 2011
Isolated congenital complete atrioventricular block (CAVB) shows a close association with maternal anti-Ro/SSA and anti-La/SSB antibodies; the highest relative risks of CAVB are seen in offspring of mothers with antibodies against 52-kDa Ro and 48-kDa La proteins.
Management of mixed dementia.
Gold et al., Genève, Switzerland. In Drugs Aging, 2010
There is only one original randomized clinical trial on (acetyl)cholinesterase inhibitor therapy (GAL-INT-6, galantamine) for MD; the other studies are post hoc analyses of AD trial subgroups (AD2000, donepezil) or of VaD trial subgroups (VantagE, rivastigmine).
Common integration sites for MMTV in viral induced mouse mammary tumors.
Smith et al., Bethesda, United States. In J Mammary Gland Biol Neoplasia, 2008
Genes commonly affected by MMTV insertion in multiple individual tumors include, the Wnt, FGF, RSpo gene families as well as eIF3e and Notch4.
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