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Membrane protein, palmitoylated 1, 55kDa

38-kDa, MPPI, erythrocyte membrane protein-1, FKBP38
This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, fibrillin-1, V1a
Papers on 38-kDa
Mitochondria: FKBP38 and mitochondrial degradation.
Nakayama et al., Fukuoka, Japan. In Int J Biochem Cell Biol, Jun 2014
FK506-binding protein 38 (FKBP38) is a membrane chaperone that is localized predominantly to mitochondria and contains a COOH-terminal tail anchor.
Epithelial-mesenchymal transition in human gastric cancer cell lines induced by TNF-α-inducing protein of Helicobacter pylori.
Suganuma et al., Saitama, Japan. In Int J Cancer, Jun 2014
Tipα acts as a homodimer with 38-kDa protein, whereas del-Tipα is an inactive monomer.
Effect of hypoxia on angiogenesis related factors in glioblastoma cells.
Allalunis-Turner et al., Edmonton, Canada. In Oncol Rep, Apr 2014
Angiostatins were detected in all GBM cell lines and were increased by hypoxia while the angiostatin isoform of 38-kDa was the most abundant in GBM cells under aerobic and hypoxic conditions.
Exploration of novel cellular and serological antigen biomarkers in the ORFeome of Mycobacterium tuberculosis.
Jin et al., Beijing, China. In Mol Cell Proteomics, Mar 2014
Of the 1,250 detected proteins, 29 were present at a higher level relative to the commercialized 38-kDa protein.
Ca2+/S100 proteins inhibit the interaction of FKBP38 with Bcl-2 and Hsp90.
Kobayashi et al., Japan. In Biochem J, Mar 2014
FKBP38 (FK506-binding protein 38), a membrane-anchored TPR (tetratricopeptide repeat)-containing immunophilin, regulates signalling pathways such as cell survival, apoptosis, proliferation and metastasis.
Small-animal single-photon emission computed tomographic imaging of the brain serotoninergic systems in wild-type and mdr1a knockout rats.
Millet et al., In Mol Imaging, Jan 2014
Thus, we compared the performances of 123I-p-MPPI, 123I-R91150, 123I-SB207710, and 123I-ADAM radioligands, for imaging of their respective targets (5-hydroxytryptamine [5-HT]1A, 5-HT2A, 5-HT4, and serotonin transporter [SERT]), in WT and Mdr1a knockout (KO) rats.
Virulence genes and genetic diversity of Streptococcus suis serotype 2 isolates from Thailand.
Srimanote et al., Thailand. In Transbound Emerg Dis, Nov 2013
These isolates were tested for the presence of six virulence-associated genes: an arginine deiminase (arcA), a 38-kDa protein and protective antigen (bay046), an extracellular factor (epf), an hyaluronidase (hyl), a muramidase-released protein (mrp) and a suilysin (sly).
Role of Bcl-2 in tumour cell survival and implications for pharmacotherapy.
Dass et al., Australia. In J Pharm Pharmacol, 2012
FKBP-38 is a binding protein that has been discovered to be upregulated in highly aggressive cancers and binds to Bcl-2 rather than the pro-apoptotics to induce a state of hyper-mitosis.
FK506 binding protein 8 peptidylprolyl isomerase activity manages a late stage of cystic fibrosis transmembrane conductance regulator (CFTR) folding and stability.
Balch et al., Los Angeles, United States. In J Biol Chem, 2012
FK506 binding protein 8 peptidylprolyl isomerase activity manages a late stage of cystic fibrosis transmembrane conductance regulator (CFTR) folding and stability
Palmitoylation of MPP1 (membrane-palmitoylated protein 1)/p55 is crucial for lateral membrane organization in erythroid cells.
Sikorski et al., Wrocław, Poland. In J Biol Chem, 2012
pathophysiological relationship between the loss of MPP1-directed palmitoylation activity and perturbed lateral membrane organization.
The FKBP38 catalytic domain binds to Bcl-2 via a charge-sensitive loop.
Lücke et al., Halle, Germany. In J Biol Chem, 2012
The derived structure model of the complex between Bcl-2 and the FKBP38 catalytic domain features both electrostatic and hydrophobic intermolecular contacts and provides a rationale for the regulation of the FKBP38/Bcl-2 interaction by Ca(2+).
FKBP38 peptidylprolyl isomerase promotes the folding of cystic fibrosis transmembrane conductance regulator in the endoplasmic reticulum.
Wang et al., Toledo, United States. In J Biol Chem, 2012
Data support a dual role for FKBP38 in regulating CFTR synthesis and post-translational folding.
Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox.
Pastan et al., Bethesda, United States. In Clin Cancer Res, 2011
Moxetumomab pasudotox, previously called HA22 or CAT-8015, is a recombinant immunotoxin composed of the Fv fragment of an anti-CD22 monoclonal antibody fused to a 38-kDa fragment of Pseudomonas exotoxin A, called PE38.
FKBP38-Bcl-2 interaction: a novel link to chemoresistance.
Yoon et al., Singapore, Singapore. In Curr Opin Pharmacol, 2011
FKBP38, a noncanonical member of the immunosuppressive drug FK506 binding protein (FKBP) family members, possesses an inducible rotamase.
From cell death to viral replication: the diverse functions of the membrane-associated FKBP38.
Lücke et al., Bethesda, United States. In Curr Opin Pharmacol, 2011
FKBP38 is in many ways an exceptional member of the FK506-binding proteins.
Temporal expression pattern of Fkbp8 in rodent cochlea.
Blin et al., Tübingen, Germany. In Cell Physiol Biochem, 2010
In pre-hearing time Fkbp8-specific signal was also observed in the tectorial membrane, whose alpha- and beta-Tectorin components show similar time-dependent expression of mRNA as Fkbp8.
FK506 binding proteins as targets in anticancer therapy.
Romano et al., Napoli, Italy. In Anticancer Agents Med Chem, 2010
Recent studies have focused on FKBPs in apoptosis regulation: Targeting of FKBP12 promotes apoptosis in chronic lymphocytic leukemia, FKBP38 knockdown sensitizes hepatoma cells to apoptosis, and FKBP51 silencing overcomes resistance to apoptosis in acute lymphoblastic leukemia, prostate cancer, melanoma, and glioma.
Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.
Jiang et al., Pittsburgh, United States. In Science, 2007
findings suggest that FKBP38 is an endogenous inhibitor of mTOR, whose inhibitory activity is antagonized by Rheb in response to growth factor stimulation and nutrient availability
Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria.
Wellems et al., Bethesda, United States. In Nature, 2005
falciparum erythrocyte membrane protein-1), correlates with these findings.
Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis.
Nakayama et al., Fukuoka, Japan. In Nat Cell Biol, 2003
Here we show that mitochondrial FK506-binding protein 38 (FKBP38), unlike FKBP12, binds to and inhibits calcineurin in the absence of the immunosuppressant FK506, suggesting that FKBP38 is an inherent inhibitor of this phosphatase.
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