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Membrane protein, palmitoylated 1, 55kDa

38-kDa, MPPI, erythrocyte membrane protein-1, FKBP38
This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Papers on 38-kDa
FK506 binding protein 8 peptidylprolyl isomerase activity manages a late stage of cystic fibrosis transmembrane conductance regulator (CFTR) folding and stability.
GeneRIF
Balch et al., Los Angeles, United States. In J Biol Chem, 2012
FK506 binding protein 8 peptidylprolyl isomerase activity manages a late stage of cystic fibrosis transmembrane conductance regulator (CFTR) folding and stability
The FKBP38 catalytic domain binds to Bcl-2 via a charge-sensitive loop.
GeneRIF
Lücke et al., Halle, Germany. In J Biol Chem, 2012
The derived structure model of the complex between Bcl-2 and the FKBP38 catalytic domain features both electrostatic and hydrophobic intermolecular contacts and provides a rationale for the regulation of the FKBP38/Bcl-2 interaction by Ca(2+).
Palmitoylation of MPP1 (membrane-palmitoylated protein 1)/p55 is crucial for lateral membrane organization in erythroid cells.
GeneRIF
Sikorski et al., Wrocław, Poland. In J Biol Chem, 2012
pathophysiological relationship between the loss of MPP1-directed palmitoylation activity and perturbed lateral membrane organization.
FKBP38 peptidylprolyl isomerase promotes the folding of cystic fibrosis transmembrane conductance regulator in the endoplasmic reticulum.
GeneRIF
Wang et al., Toledo, United States. In J Biol Chem, 2012
Data support a dual role for FKBP38 in regulating CFTR synthesis and post-translational folding.
Temporal expression pattern of Fkbp8 in rodent cochlea.
GeneRIF
Blin et al., Tübingen, Germany. In Cell Physiol Biochem, 2010
In pre-hearing time Fkbp8-specific signal was also observed in the tectorial membrane, whose alpha- and beta-Tectorin components show similar time-dependent expression of mRNA as Fkbp8.
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