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Membrane protein, palmitoylated 1, 55kDa

38-kDa, MPPI, erythrocyte membrane protein-1, FKBP38
This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, fibrillin-1, V1a
Papers on 38-kDa
Multifocal Lymphangioendotheliomatosis With Thrombocytopenia: Clinical Features and Response to Sirolimus.
New
Maruani et al., Rennes, France. In Pediatrics, 31 Aug 2015
Histologically, all were negative for glucose transporter 1 and positive for the lymphatic marker lymphatic vessel endothelial hyaluronan receptor 1 or D2-40 (∼38-kDa O-linked transmembrane sialoglycoprotein podoplanin).
FKBP25 and FKBP38 regulate non-capacitative calcium entry through TRPC6.
New
Redondo et al., Cáceres, Spain. In Biochim Biophys Acta, 31 Aug 2015
We have found interaction between FKBP38 and other FKBPs, like FKBP25, FKBP12 and FKBP52 that were not affected by FK506, as well as with calmodulin (CaM).
Role of mTOR1 and mTOR2 complexes in MEG-01 cell physiology.
New
Redondo et al., Cáceres, Spain. In Thromb Haemost, 23 Aug 2015
By using mTOR antagonists and overexpressing FKBP38, we have explored the role of both mTOR complexes in proliferation, apoptosis, maturation-like mechanisms, endoplasmic reticulum-stress and the intracellular location of both active mTOR complexes during MEG-01 cell stimulation with TPO.
Tetratricopeptide repeat domain 9A negatively regulates estrogen receptor alpha activity.
New
Lin et al., Singapore, Singapore. In Int J Biol Sci, Dec 2014
Although TTC9A does not bind to ERα or its chaperone protein Hsp90 directly, TTC9A strongly interacts with FKBP38 and FKBP51, both of which interact with ERα and Hsp90 and modulate ERα activity.
Identification of proteins associated with Mycobacterium tuberculosis virulence pathway by their polar profile.
New
Gimbel et al., Mexico. In Acta Biochim Pol, Dec 2014
The test considered the totality of proteins cataloged in the main domains: fungi, bacteria, and viruses from three databases: Antimicrobial Peptide Database (APD2), Tuberculist Database, Uniprot Database, and four antigens of Mycobacterium tuberculosis: PstS-1, 38-kDa, 19-kDa, and H37Rv ORF.
Development of genetically engineered iNKT cells expressing TCRs specific for the M. tuberculosis 38-kDa antigen.
New
Ma et al., Guangzhou, China. In J Transl Med, Dec 2014
STUDY DESIGN AND METHODS: In the present study, an Mtb 38-kDa antigen-specific T cell receptor (TCR) was isolated from human CD8(+) T cells stimulated by 38-kDa antigen in vitro, and then transduced into primary iNKT cells by retrovirus vector.
Mechanistic Studies of the Negative Epistatic Malaria-protective Interaction Between Sickle Cell Trait and α(+)thalassemia.
New
Williams et al., Kilifi, Kenya. In Ebiomedicine, Dec 2014
We studied cytoadhesion of parasitized RBCs (pRBCs) to the endothelial receptors CD36 and ICAM1, rosetting of pRBCs with uninfected RBCs, and pRBC surface expression of the parasite-derived adhesion molecule P. falciparum Erythrocyte Membrane Protein-1 (PfEMP1).
Mitochondria: FKBP38 and mitochondrial degradation.
Review
New
Nakayama et al., Fukuoka, Japan. In Int J Biochem Cell Biol, Jun 2014
FK506-binding protein 38 (FKBP38) is a membrane chaperone that is localized predominantly to mitochondria and contains a COOH-terminal tail anchor.
Role of Bcl-2 in tumour cell survival and implications for pharmacotherapy.
Review
Dass et al., Australia. In J Pharm Pharmacol, 2012
FKBP-38 is a binding protein that has been discovered to be upregulated in highly aggressive cancers and binds to Bcl-2 rather than the pro-apoptotics to induce a state of hyper-mitosis.
FK506 binding protein 8 peptidylprolyl isomerase activity manages a late stage of cystic fibrosis transmembrane conductance regulator (CFTR) folding and stability.
GeneRIF
Balch et al., Los Angeles, United States. In J Biol Chem, 2012
FK506 binding protein 8 peptidylprolyl isomerase activity manages a late stage of cystic fibrosis transmembrane conductance regulator (CFTR) folding and stability
Palmitoylation of MPP1 (membrane-palmitoylated protein 1)/p55 is crucial for lateral membrane organization in erythroid cells.
GeneRIF
Sikorski et al., Wrocław, Poland. In J Biol Chem, 2012
pathophysiological relationship between the loss of MPP1-directed palmitoylation activity and perturbed lateral membrane organization.
The FKBP38 catalytic domain binds to Bcl-2 via a charge-sensitive loop.
GeneRIF
Lücke et al., Halle, Germany. In J Biol Chem, 2012
The derived structure model of the complex between Bcl-2 and the FKBP38 catalytic domain features both electrostatic and hydrophobic intermolecular contacts and provides a rationale for the regulation of the FKBP38/Bcl-2 interaction by Ca(2+).
FKBP38 peptidylprolyl isomerase promotes the folding of cystic fibrosis transmembrane conductance regulator in the endoplasmic reticulum.
GeneRIF
Wang et al., Toledo, United States. In J Biol Chem, 2012
Data support a dual role for FKBP38 in regulating CFTR synthesis and post-translational folding.
Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox.
Review
Pastan et al., Bethesda, United States. In Clin Cancer Res, 2011
Moxetumomab pasudotox, previously called HA22 or CAT-8015, is a recombinant immunotoxin composed of the Fv fragment of an anti-CD22 monoclonal antibody fused to a 38-kDa fragment of Pseudomonas exotoxin A, called PE38.
FKBP38-Bcl-2 interaction: a novel link to chemoresistance.
Review
Yoon et al., Singapore, Singapore. In Curr Opin Pharmacol, 2011
FKBP38, a noncanonical member of the immunosuppressive drug FK506 binding protein (FKBP) family members, possesses an inducible rotamase.
From cell death to viral replication: the diverse functions of the membrane-associated FKBP38.
Review
Lücke et al., Bethesda, United States. In Curr Opin Pharmacol, 2011
FKBP38 is in many ways an exceptional member of the FK506-binding proteins.
Temporal expression pattern of Fkbp8 in rodent cochlea.
GeneRIF
Blin et al., Tübingen, Germany. In Cell Physiol Biochem, 2010
In pre-hearing time Fkbp8-specific signal was also observed in the tectorial membrane, whose alpha- and beta-Tectorin components show similar time-dependent expression of mRNA as Fkbp8.
Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.
Impact
GeneRIF
Jiang et al., Pittsburgh, United States. In Science, 2007
findings suggest that FKBP38 is an endogenous inhibitor of mTOR, whose inhibitory activity is antagonized by Rheb in response to growth factor stimulation and nutrient availability
Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria.
Impact
Wellems et al., Bethesda, United States. In Nature, 2005
falciparum erythrocyte membrane protein-1), correlates with these findings.
Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis.
Impact
Nakayama et al., Fukuoka, Japan. In Nat Cell Biol, 2003
Here we show that mitochondrial FK506-binding protein 38 (FKBP38), unlike FKBP12, binds to and inhibits calcineurin in the absence of the immunosuppressant FK506, suggesting that FKBP38 is an inherent inhibitor of this phosphatase.
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