GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Membrane protein, palmitoylated 1, 55kDa
38-kDa, MPPI, erythrocyte membrane protein-1, FKBP38
This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] (from
NCBI)
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Papers on
38-kDa
Spatial and temporal mapping of the PfEMP1 export pathway in Plasmodium falciparum.
New
Melbourne, Australia. In Cell Microbiol, 20 Mar 2013
One key virulence protein, P. falciparum Erythrocyte Membrane Protein-1 (PfEMP1), is trafficked to the surface of the infected RBC, where it mediates adhesion to the vascular endothelium.
Prolyl Hydroxylase Domain Protein 2 (PHD2) Binds a Pro-Xaa-Leu-Glu Motif, Linking it to the Heat Shock Protein 90 Pathway.
New
United States. In J Biol Chem, 14 Mar 2013
In the present report, we show that the Heat Shock Protein 90 (HSP90) co-chaperones p23 and FKBP38 interact via a conserved Pro-Xaa-Leu-Glu motif (where Pro = Proline, Xaa = any amino acid, Leu = Leucine, Glu = Glutamic acid) in these proteins with the N-terminal Myeloid Nervy and DEAF-1 (MYND)-type zinc finger of PHD2.
Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations.
New
Zürich, Switzerland. In J Neurosci, 02 Mar 2013
We previously identified the FK506 binding protein 38 (FKBP38) as a negative regulator of PHD2.
Selective escape of proteins from the mitochondria during mitophagy.
New
Fukuoka, Japan. In Nat Commun, 01 Mar 2013
Here we show that certain mitochondrial outer membrane proteins, including FKBP38 and Bcl-2, translocate from the mitochondria to the endoplasmic reticulum (ER) during mitophagy, thereby escaping degradation by autophagosomes.
Serodiagnostic potential of Mycobacterium avium MAV2054 and MAV5183 proteins.
New
Taejŏn, South Korea. In Clin Vaccine Immunol, 28 Feb 2013
In this study, the serodiagnostic potential of the newly identified MAV2054 and MAV5183 proteins was evaluated in subjects with MAC-PD, pulmonary TB, or latent TB and in noninfected healthy controls (HC), together with HspX and the 38-kDa antigen, well-known serodiagnostic M. tuberculosis antigens.
Insulator-like pairing elements regulate silencing and mutually exclusive expression in the malaria parasite Plasmodium falciparum.
New
Jerusalem, Israel. In Proc Natl Acad Sci U S A, Jan 2013
falciparum erythrocyte membrane protein-1" encoded by the var multicopy gene family.
Diagnosis of intestinal tuberculosis using a monoclonal antibody to Mycobacterium tuberculosis.
New
Okinawa, Japan. In World J Gastroenterol, Jan 2013
For the present study, archived formalin-fixed paraffin-embedded (FFPE) intestinal tissue samples were immunohistochemically stained using a commercially available species-specific monoclonal antibody to the 38-kDa antigen of the M. tuberculosis complex.
Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox.
Review
Bethesda, United States. In Clin Cancer Res, 2011
Moxetumomab pasudotox, previously called HA22 or CAT-8015, is a recombinant immunotoxin composed of the Fv fragment of an anti-CD22 monoclonal antibody fused to a 38-kDa fragment of Pseudomonas exotoxin A, called PE38.
Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect.
GeneRIF
Urbana, United States. In J Biol Chem, 2011
a dual mechanism for PA activation of mTORC1: PA displaces FKBP38 from mTOR and allosterically stimulates the catalytic activity of mTORC1.
FKBP38-Bcl-2 interaction: a novel link to chemoresistance.
Review
Singapore, Singapore. In Curr Opin Pharmacol, 2011
FKBP38, a noncanonical member of the immunosuppressive drug FK506 binding protein (FKBP) family members, possesses an inducible rotamase.
From cell death to viral replication: the diverse functions of the membrane-associated FKBP38.
Review
Bethesda, United States. In Curr Opin Pharmacol, 2011
FKBP38 is in many ways an exceptional member of the FK506-binding proteins.
Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.
GeneRIF
Gaziantep, Turkey. In Endocr Pathol, 2011
MPP1 gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma.
The essential role of FKBP38 in regulating phosphatase of regenerating liver 3 (PRL-3) protein stability.
GeneRIF
Taejŏn, South Korea. In Biochem Biophys Res Commun, 2011
These results demonstrate that FKBP38 is a novel regulator of the oncogenic protein PRL-3 abundance and that alteration in the stability of PRL-3 can have a dramatic impact on cell proliferation.
FK506 binding proteins as targets in anticancer therapy.
Review
Napoli, Italy. In Anticancer Agents Med Chem, 2010
Recent studies have focused on FKBPs in apoptosis regulation: Targeting of FKBP12 promotes apoptosis in chronic lymphocytic leukemia, FKBP38 knockdown sensitizes hepatoma cells to apoptosis, and FKBP51 silencing overcomes resistance to apoptosis in acute lymphoblastic leukemia, prostate cancer, melanoma, and glioma.
New structural aspects of FKBP38 activation.
GeneRIF
Halle, Germany. In Biol Chem, 2010
novel insights into the structural arrangement of FKBP38/calmodulin complex
Gelsolin plays a role in the actin polymerization complex of hair cell stereocilia.
GeneRIF
United Kingdom. In Plos One, 2009
Gelsolin was identified as the additional interacting partners to p55 in the whirlin interactome of hair cell stereocilia.
Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms.
Review
Cardiff, United Kingdom. In Cell Signal, 2009
Also discussed are current findings that have unravelled a series of novel mTORC1-associated proteins that directly control the activity of mTORC1 and include PRAS40, FKBP38, Rag GTPases and RalA.
Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.
Impact
GeneRIF
Pittsburgh, United States. In Science, 2007
findings suggest that FKBP38 is an endogenous inhibitor of mTOR, whose inhibitory activity is antagonized by Rheb in response to growth factor stimulation and nutrient availability
Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria.
Impact
Bethesda, United States. In Nature, 2005
falciparum erythrocyte membrane protein-1), correlates with these findings.
Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis.
Impact
Fukuoka, Japan. In Nat Cell Biol, 2003
Here we show that mitochondrial FK506-binding protein 38 (FKBP38), unlike FKBP12, binds to and inhibits calcineurin in the absence of the immunosuppressant FK506, suggesting that FKBP38 is an inherent inhibitor of this phosphatase.
