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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PDPK1 3-phosphoinositide dependent protein kinase-1

3-phosphoinositide-dependent protein kinase 1, PDPK1
Top mentioned proteins: Akt, PTEN, PI3K, HAD, mTOR
Papers on 3-phosphoinositide-dependent protein kinase 1
Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations.
New
Abel et al., Salt Lake City, United States. In J Mol Cell Cardiol, Dec 2015
Phosphoinositide-dependent protein kinase-1 (PDPK1) is an important mediator of phosphatidylinositol 3-kinase (PI3K) signaling.
PDK1: A signaling hub for cell migration and tumor invasion.
Review
New
Primo et al., Italy. In Biochim Biophys Acta, Dec 2015
3-Phosphoinositide dependent protein kinase-1 (PDK1 or PDPK1) is an ancient serine-threonine kinase belonging to AGC kinase family.
A Novel Inhibitor of AKT1-PDPK1 Interaction Efficiently Suppresses the Activity of AKT Pathway and Restricts Tumor Growth In Vivo.
New
Jaks et al., Tartu, Estonia. In Mol Cancer Ther, Nov 2015
To find inhibitors of AKT1 signaling with principally novel mechanism of action, we carried out a live cell-based screen for small molecule inhibitors of physical interaction between AKT1 and its primary activator PDPK1.
Gene Signatures Stratify Computed Tomography Screening Detected Lung Cancer in High-Risk Populations.
New
Pezzella et al., Radcliffe, United Kingdom. In Ebiomedicine, Aug 2015
Pathway analyses revealed tumours detected in later years enrichment of the PI3K/PTEN/AKT pathway, with up-regulation of PDPK1, ITGB1 and down-regulation of FOXO1A.
Molecular signatures of mRNAs and miRNAs as prognostic biomarkers in pancreatobiliary and intestinal types of periampullary adenocarcinomas.
New
Kure et al., Oslo, Norway. In Mol Oncol, Apr 2015
For the pancreatobiliary type the genes ATM, PTEN, RB1 and the miRNAs miR-592 and miR-497, and for the intestinal type the genes PDPK1, PIK3R2, G6PC and the miRNAs miR-127-3p, miR-377* were linked to enriched pathways and identified as prognostic markers.
Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple myeloma.
Taniwaki et al., Kyoto, Japan. In Cancer Res, 2015
Herein, we identified that 3-phosphoinositide-dependent protein kinase 1 (PDPK1), a serine threonine kinase, is expressed and active in all eleven multiple myeloma-derived cell lines examined regardless of the type of cytogenetic abnormality, the mutation state of RAS and FGFR3 genes, or the activation state of ERK and AKT.
RNA-seq identifies a role for the PPARβ/δ inverse agonist GSK0660 in the regulation of TNFα-induced cytokine signaling in retinal endothelial cells.
Penn et al., Nashville, United States. In Mol Vis, 2014
RNA-seq validation was performed using qRT-PCR using the primers for ANGPTL4, CCL8, NOV, CXCL10, and PDPK1.
Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier.
Ochiya et al., Tokyo, Japan. In Nat Commun, 2014
Importantly, miR-181c promotes the destruction of BBB through the abnormal localization of actin via the downregulation of its target gene, PDPK1.
MiR-375 promotes redifferentiation of adult human β cells expanded in vitro.
Efrat et al., Tel Aviv-Yafo, Israel. In Plos One, 2014
These effects, which are reproducible in cells derived from multiple human donors, are likely mediated by repression of PDPK1 transcripts and indirect downregulation of GSK3 activity.
Upregulation of the PI3K/Akt pathway in the tumorigenesis of canine thyroid carcinoma.
Mol et al., Merelbeke, Belgium. In J Vet Intern Med, 2014
METHODS: Quantitative RT-PCR was performed for VEGFR-1, VEGFR-2, EGFR, PIK3CA, PIK3CB, PDPK1, PTEN, AKT1, AKT2, COX-2, and CALCA.
Novel signaling axis for ROS generation during K-Ras-induced cellular transformation.
Lee et al., Seoul, South Korea. In Cell Death Differ, 2014
Of note, PKCδ, when it was activated by PDPK1, directly bound to the SH3-N domain of p47(phox) and catalyzed the phosphorylation on Ser348 and Ser473 residues of p47(phox) C-terminal in a K-Ras-dependent manner, finally leading to its membrane translocation.
The ovarian reserve of primordial follicles and the dynamic reserve of antral growing follicles: what is the link?
Review
Monget et al., France. In Biol Reprod, 2014
The dynamics of both follicular reserves appears to result from the fine tuning of regulations involving two main pathways, the phosphatase and tensin homolog (PTEN)/phosphatidylinositol-3 kinase (PI3K)/3-phosphoinositide-dependent protein kinase-1 (PDPK1)/v-akt murine thymoma viral oncogene homolog 1 (AKT1) and the bone morphogenetic protein (BMP)/anti-Müllerian hormone (AMH)/SMAD signaling pathways.
Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.
Lipkowitz et al., In Breast Cancer Res, 2013
Gene-network analysis identified four genes (PDPK1, IKBKB, SRC, and BCL2L1) that formed key nodes within the interaction network of negative regulators.
Prognostic significance of MTOR pathway component expression in neuroendocrine tumors.
Impact
Kulke et al., Boston, United States. In J Clin Oncol, 2013
We failed to identify clinical correlations associated with expression of the upstream regulators TSC1, TSC2, AKT, p-AKT, PDPK1, PTEN, PIK3R1, or PIK3CA.
3-Phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer.
Review
Falasca et al., London, United Kingdom. In Cancer Manag Res, 2012
It should be noted that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is a protein encoded by the PDPK1 gene, which plays a key role in the signaling pathways activated by several growth factors and hormones.
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