3 beta-hydroxysteroid dehydrogenase
Wt1 is involved in leydig cell steroid hormone biosynthesis by regulating paracrine factor expression in mice.
Beijing, China. In Biol Reprod, 2014
In the present study, we found that Wt1 is also required for steroidogenesis in Leydig cells and that deletion of the Wt1 gene resulted in defects in testosterone biosynthesis and downregulation of steroidogenic gene expression, including cytochrome P450 side-chain cleavage (P450scc), steroidogenic acute regulatory protein (StAR), 3beta-hydroxysteroid dehydrogenase I (3beta-HSD), and cytochrome P450 17A1 (Cyp17a1).
Placental steroids in cattle: hormones, placental growth factors or by-products of trophoblast giant cell differentiation?
Gießen, Germany. In Exp Clin Endocrinol Diabetes, 2008
The down-regulation of P450scc and P450c17 and the up-regulation of 3beta-HSD and aromatase during the differentiation of TGC from UTC in parallel with the up-regulation of ER beta and estrogen sulfotransferase in maturing TGC suggests a function of placental estrogens primarily as autoor intracrine regulators during this process and assigns to conjugated placental estrogens a role as inactivated by-products of TGC differentiation intended for excretion.
Expression of steroidogenic enzymes and sex-steroid receptors in human prostate.
Québec, Canada. In Best Pract Res Clin Endocrinol Metab, 2008
The enzymes 3beta-hydroxysteroid dehydrogenase (3beta-HSD), which converts dehydroepiandrosterone (DHEA) into androstenedione, and type 5 17beta-HSD, which catalyzes the reduction of androstenedione to testosterone, have been localized in basal cells of alveoli as well as in stromal cells and endothelial cells of blood vessels.
Neuroprogesterone: key to estrogen positive feedback?
Los Angeles, United States. In Brain Res Rev, 2008
In support of the idea that estradiol induces neuroprogesterone, estradiol increased expression of the progesterone-synthesizing enzyme 3beta-hydroxysteroid dehydrogenase (3beta-HSD) in the hypothalamus before the LH surge.
3beta-HSD activates DHEA in the songbird brain.
Los Angeles, United States. In Neurochem Int, 2008
Over the past decade, we have obtained considerable evidence from avian studies demonstrating that (1) DHEA is an important circulating prohormone in songbirds and (2) the enzyme 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD), responsible for converting DHEA into a more active androgen, is expressed at high levels in the songbird brain.