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Heterogeneous nuclear ribonucleoprotein H3

2H9
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, fibrillin-1, CAN, HAD, CIs
Papers on 2H9
Tacrolimus fails to regulate collagen expression in dermal fibroblasts.
Kuang et al., Portland, United States. In J Surg Res, 2013
Collagen pathways were not blocked after tacrolimus exposure in any of the fibroblast groups; we validated these findings using quantitative polymerase chain reaction for collagen 1 and 3. Microarray gene expression of NME/NM23 nucleoside diphosphate kinase 1 and heterogeneous nuclear ribonucleoprotein H3-2H9 were significantly downregulated (P < 0.05) by tacrolimus in both HTS and keloid fibroblast populations but not normal fibroblasts.
Excellent optical thermometry based on short-wavelength upconversion emissions in Er3+/Yb3+ codoped CaWO4.
Cao et al., Harbin, China. In Opt Lett, 2013
Excited by a 980 nm laser, upconversion emissions centered at 384 (Er3+:4G11/2→4I15/2) and 408 nm (Er3+:2H9/2→4I15/2) in Er3+/Yb3+ codoped polycrystalline CaWO4 were successfully obtained.
Generation of monoclonal antibody against trans-resveratrol.
Bashmakov et al., Cambridge, United Kingdom. In Hybridoma (larchmt), 2012
Expansion of the primary clones, their subsequent screening, and subcloning narrowed our search to allowed isolation of two IgG1a-producing hybridomas designated as 2H9 and 1B1.
Identification of Hnrph3 as an autoantigen for acute anterior uveitis.
GeneRIF
Li et al., Miami, United States. In Clin Immunol, 2011
Using ORF phage display, heterogeneous nuclear ribonucleoprotein H3 (Hnrph3) was, among other candidates, identified as an autoantigen for acute anterior uveitis.
Synthesis and luminescence properties of Er3+ doped Y(OH)3, NH4Y3F10, and YF3 nanocrystals.
Ding et al., Changchun, China. In J Nanosci Nanotechnol, 2010
The 2H9/2, --> 4I15/2, 4F3/2(4F5/2) --> 4I15/2, and 4S3/2 --> 4I15/2 were observed, and the most intense peak was centered at 436 nm [4F3/2(4F5/2) --> 4I15/2].
Role of cellular RNA processing factors in human immunodeficiency virus type 1 mRNA metabolism, replication, and infectivity.
Caputi et al., Boca Raton, United States. In J Virol, 2009
To understand the role of these protein families within the context of the full replicating virus, we altered the expression levels of hnRNPs H, F, 2H9, GRSF1, A1, A2, and A3 and SR proteins SC35, SF2, and SRp40 in HEK 293 cells transfected with the proviral clone pNL4-3.
Mapping of conformational mAb epitopes to the C domain of human angiotensin I-converting enzyme.
Danilov et al., Chicago, United States. In J Proteome Res, 2008
mAbs 1B8 and 3F10 were especially sensitive to the composition of the N-glycan attached to Asn 731; mAbs 2H9 and 3F11 detected the glycosylation status of the glycan attached to Asn 685 and perhaps Asn1162; and mAb 1E10 and 4E3 recognized the glycan on Asn 666.
[Characteristics of monoclonal antibody binding with the C domain of human angiotensin converting enzyme].
Kost et al., In Bioorg Khim, 2008
The dissociation constants of complexes of two mAbs, IB8 and 2H9, with tACE were 2.3 +/- 0.4 and 2.5 +/- 0.4 nM, respectively, for recombinant tACE and 1.6 +/- 0.3 nM for spermatozoid tACE.
Development of fragment-specific osteopontin antibodies and ELISA for quantification in human metastatic breast cancer.
Liaw et al., Portland, United States. In Bmc Cancer, 2007
Epitopes recognized by four antibodies (2C5, 2F10, 2H9, and 2E11) map to N-terminal OPN (aa1-166); one (1F11) maps to C-terminal OPN (aa167-314).
Members of the heterogeneous nuclear ribonucleoprotein H family activate splicing of an HIV-1 splicing substrate by promoting formation of ATP-dependent spliceosomal complexes.
Caputi et al., Boca Raton, United States. In J Biol Chem, 2007
Our data indicate that hnRNPs H, H', F, 2H9, and GRSF-1 bind the consensus motif DGGGD (where D is U, G, or A) and aggregate in a multimeric complex.
Enhancement of luminescence properties in Er3+ doped TeO2-Na2O-PbX (X=O and F) ternary glasses.
Rai et al., Benares, India. In Spectrochim Acta A Mol Biomol Spectrosc, 2007
The infrared to visible upconversion emission bands are observed at 410, 525, 550 and 658 nm, due to the 2H9/2-->4I15/2, 2H11/2-->4I15/2, 4S3/2-->4I15/2, 4F9/2-->4I15/2 transitions respectively, on excitation with 797 nm laser line.
Clinical role of thymidine phosphorylase and dihydropyrimidine dehydrogenase in colorectal cancer treated with postoperative fluoropyrimidine.
Saito et al., Ōsaka, Japan. In Hepatogastroenterology, 2005
Now, new monoclonal antibodies for human TP (1C6-203) and human DPD (2H9-1b) are available.
Inhibition of prion propagation in scrapie-infected mouse neuroblastoma cell lines using mouse monoclonal antibodies against prion protein.
Matsuda et al., Hiroshima, Japan. In Biochem Biophys Res Commun, 2005
We screened six mouse monoclonal antibodies (mAbs) against prion protein (PrP), which were previously established in our laboratory, for inhibitory activity against PrP(Sc)-accumulation in scrapie-infected cell lines and identified two mAbs, 3S9 and 2H9, as possessing this inhibitory activity.
Laser activity at 1.18, 1.07, and 0.97 microm in the low-phonon-energy hosts KPb2Br5 and RbPb2Br5 doped with Nd3+.
Burger et al., Livermore, United States. In Opt Lett, 2005
Laser operation at the new wavelengths 1.18 and 0.97 microm that resulted from the 4F5/2 + 2H9/2 - 4IJ transitions (J=13/2 and J=11/2) in Nd:RPB was achieved in a solid-state laser material.
Targeting human cancer cells with VEGF receptor-2-directed liposomes.
Ballmer-Hofer et al., China. In Oncol Rep, 2005
This antibody, scFvVR-2H9 was coupled to liposomes and used to specifically target VEGFR-2-expressing human cancer cells in culture.
EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer.
Polakis et al., San Francisco, United States. In Cancer Res, 2004
One of the MAbs, 2H9, effectively blocked the interaction of ephB2 with ephrin ligands and inhibited the resulting autophosphorylation of the receptor.
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