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Dihydrodiol dehydrogenase

2Dd, dimeric dihydrodiol dehydrogenase
This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MHC, CAN, HAD, ACID, CD45
Papers on 2Dd
Increased night duty loading of physicians caused elevated blood pressure and sympathetic tones in a dose-dependent manner.
New
Guo et al., Taipei, Taiwan. In Int Arch Occup Environ Health, Sep 2015
Heart rate variability (HRV), blood pressure (BP), and other stress markers of 12 attending physicians were compared during different duty loads: non-duty day (NDD), duty day with one duty area and three wards (1DD), and duty day with two duty areas and six wards (2DD).
The G1057D polymorphism of insulin receptor substrate-2 associated with gestational diabetes mellitus.
Cayan et al., Edirne, Turkey. In Gynecol Endocrinol, 2014
p = 0.076) in the individuals with the IRS-2 DD genotype compared to the GG genotype.
Depressed atrial function in diastolic dysfunction: a speckle tracking imaging study.
Aurigemma et al., Worcester, United States. In Echocardiography, 2013
METHODS: We applied STI to 50 patients with Grade 1-2 DD, comparing these results to 100 normal controls.
Insertion/deletion polymorphism of the angiotensin-converting enzyme gene in lupus nephritis among Mexicans.
Salazar-Páramo et al., Guadalajara, Mexico. In Immunopharmacol Immunotoxicol, 2013
The I/D polymorphism distribution according to histological class was class II: 1 II, 3 ID, and 1 DD; class III: 2 II, 10 ID, and 1 DD; class IV: 2 II, 9 ID, and 2 DD; class V: 2 II, 3 ID, and 4 DD; and class VI, 1 II.
Relationship between baseline resting diastolic function and exercise capacity in patients with hypertrophic cardiomyopathy undergoing treadmill stress echocardiography: a cohort study.
Jaber et al., Cleveland, United States. In Bmj Open, 2011
There were 495 remaining patients with a mean age (SD) of 50 (15) years, and 32% women among whom 102 (21%) had normal diastolic function, 243 (49%) stage 1 DD; 131 (26%) stage 2 DD and 19 (4%) stage 3 DD.
Overexpression of dihydrodiol dehydrogenase as a prognostic marker in resected gastric cancer patients.
GeneRIF
Fang et al., Taiwan. In Dig Dis Sci, 2009
Survival was significantly better in gastric cancer patients with low DDH expression.
Structural and functional features of dimeric dihydrodiol dehydrogenase.
Review
El-Kabbani et al., Australia. In Cell Mol Life Sci, 2008
Dimeric dihydrodiol dehydrogenase (DD) catalyzes the NADP(+)-dependent oxidation of trans-dihydrodiols of aromatic hydrocarbons to their corresponding catechols.
Transcriptional regulation of neuronal genes and its effect on neural functions: gene expression in response to static magnetism in cultured rat hippocampal neurons.
Review
Yoneda et al., Kanazawa, Japan. In J Pharmacol Sci, 2005
Nucleotide sequence analysis followed by BLASTN homology searching revealed high homology of these 2 DD-PCR products to the 3' non-coding regions of the mouse basic helix-loop-helix transcription factor ALF1 and that of histone H3.3A, respectively.
Structural and functional aspects of the Ly49 natural killer cell receptors.
Review
Biassoni et al., Genova, Italy. In Immunol Cell Biol, 2005
In this study, we review the function and X-ray crystal structure of the Ly49 NK cell receptors hitherto determined (Ly49A, Ly49C and Ly49I), and the structural features of the Ly49/MHC class I interaction as revealed by the X-ray crystal structures of Ly49A/H-2Dd and the recently determined Ly49C/H-2Kb.
Structure of the Ly49 family of natural killer (NK) cell receptors and their interaction with MHC class I molecules.
Review
Biassoni et al., Genova, Italy. In Immunol Res, 2003
Here we summarize the structure of Ly49 C-type lectin-like proteins hitherto solved (Ly49A, Ly49C and Ly49I) and their interaction with MHC class I molecules as determined by the co-crystal structure of Ly49A/H-2Dd and Ly49C/H-2Kb.
Structure and function of natural killer cell surface receptors.
Review
Sun et al., Rockville, United States. In Annu Rev Biophys Biomol Struct, 2002
The structures of activating and inhibitory NK cell surface receptors and their complexes with the ligands determined to date, including killer immunoglobulin-like receptors (KIRs) and their complexes with HLA molecules, CD94, Ly49A, and its complex with H-2Dd, and NKG2D receptors and their complexes with class I MHC homologs, are reviewed here.
Identity of dimeric dihydrodiol dehydrogenase as NADP(+)-dependent D-xylose dehydrogenase in pig liver.
GeneRIF
Hara et al., Gifu, Japan. In Chem Biol Interact, 2001
Comparison of other mammalian homologs with the human enzyme shows that dimeric DDs constitute a novel protein family.
Roles of His-79 and Tyr-180 of D-xylose/dihydrodiol dehydrogenase in catalytic function.
GeneRIF
Hara et al., Gifu, Japan. In Biochem Biophys Res Commun, 2000
Site-directed mutagenesis of conserved residues shows that Tyr-180 plays a critical role in the catalytic function of this enzyme, while His-79 is required in the coenzyme binding and chemical steps of the reaction.
Interaction of the NK cell inhibitory receptor Ly49A with H-2Dd: identification of a site distinct from the TCR site.
Impact
Margulies et al., Bethesda, United States. In Immunity, 1999
We describe the binding of bacterially expressed Ly49A, the prototype murine NK inhibitory receptor, to similarly engineered H-2Dd.
The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition.
Impact
Kärre et al., Stockholm, Sweden. In Immunity, 1998
The structure of H-2Dd complexed with the HIV-derived peptide P18-I10 (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A resolution.
The lectin-like NK cell receptor Ly-49A recognizes a carbohydrate-independent epitope on its MHC class I ligand.
Impact
Yokoyama et al., Saint Louis, United States. In Immunity, 1998
The mouse NK inhibitory Ly-49A receptor specifically interacts with a peptide-induced conformational determinant on its MHC class I ligand, H-2Dd.
The role of Ly49A and 5E6(Ly49C) molecules in hybrid resistance mediated by murine natural killer cells against normal T cell blasts.
Impact
Bennett et al., Dallas, United States. In Immunity, 1996
H-2Dd transgenic B6 (D8) targets are not susceptible to F1 Ly49A+ effectors.
Ly-49A, a receptor for H-2Dd, has a functional carbohydrate recognition domain.
Impact
Seaman et al., San Francisco, United States. In Immunity, 1994
Ly-49A+ murine natural killer (NK) cells cannot lyse target cells that express H-2Dd.
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