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Metallophosphoesterase domain containing 2

239FB, FaMIB, C11ORF8
This gene likely encodes a metallophosphoesterase. The encoded protein may play a role a brain development. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009] (from NCBI)
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Top mentioned proteins: CAN, MIB-1, V1a, alphaB-crystallin, MIA
Papers on 239FB
The metallophosphodiesterase Mpped2 impairs tumorigenesis in neuroblastoma.
Zollo et al., Napoli, Italy. In Cell Cycle, 2012
The overexpression of Mpped2 improves survival rate, substantially impairs tumor growth and induces neuronal differentiation.
Unique utilization of a phosphoprotein phosphatase fold by a mammalian phosphodiesterase associated with WAGR syndrome.
Podobnik et al., Ljubljana, Slovenia. In J Mol Biol, 2011
The structures of MPPED2 and two mutants show that the poor activity of MPPED2 is not only a consequence of the substitution of an active-site histidine residue by glycine but also due to binding of AMP or GMP to the active site.
Characterization of an evolutionarily conserved metallophosphoesterase that is expressed in the fetal brain and associated with the WAGR syndrome.
Visweswariah et al., Bengaluru, India. In J Biol Chem, 2009
We performed a large scale bioinformatic analysis to identify orthologs of the Rv0805 protein and identified many eukaryotic genes that included the human 239FB gene present in the region deleted in the WAGR syndrome.
Genetic background of different cancer cell lines influences the gene set involved in chromosome 8 mediated breast tumor suppression.
Scherneck et al., Berlin, Germany. In Genes Chromosomes Cancer, 2006
The expression patterns of seven genes highly expressed in the hybrids but down-regulated in the tumors and metastases (MYH11, CRYAB, C11ORF8, PDGFRL, PLAGL1, SH3BP5, and KIAA1026) were confirmed by RT-PCR and tissue microarray analyses.
Phylogenetic analysis and developmental expression of brp-like genes in amphioxus and zebrafish.
Zhang et al., Jinan, China. In Comp Biochem Physiol B Biochem Mol Biol, 2005
The putative brp-like proteins are orthologous to the ancestor of the human brain protein 239FB and 239AB.
Immunohistochemical study of MIB1 expression in phyllodes tumor and fibroadenoma.
Yoshida et al., Kagoshima, Japan. In Pathol Int, 1999
The 21/215 (9.8%) cases of FA, which were designated as FAMIB, showed a high stromal MlB1-index (more than 10/0.0625
The 239AB gene on chromosome 22: a novel member of an ancient gene family.
Ota et al., Boston, United States. In Gene, 1997
Gene 239FB, transcribed extensively in fetal brain, was isolated from the chromosome 11p13 region associated with mental retardation component of the WAGR (Wilms tumor, aniridia, genitourinary anomalies, mental retardation) syndrome.
cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region.
Bruns et al., Boston, United States. In Genomics, 1995
A new gene (239FB) with predominant and differential expression in fetal brain has recently been isolated from a chromosome 11p13-p14 boundary area near FSHB.
Kinetics of sequential metabolism. Contribution of parallel, primary metabolic pathways to the formation of a common, secondary metabolite.
Pang, Toronto, Canada. In Drug Metab Dispos, 1995
Case-independent solutions were obtained for the fractions absorbed (Fa, FaMIA, FaMIB) and the availabilities (F, F(MIA), F(MIB)) of drug and the primary metabolites, and for f1, f2, f1/f2, fMIA/fMIB, and (f1fMIA)/(f2fMIB) (ratio of effective clearances of MII formation from D via MIA and MIB).
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