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Heparan sulfate 2-O-sulfotransferase 1

2-O-sulfotransferase, Hs2st, heparan sulfate 2-O-sulfotransferase, HS2ST1, HS 2-O-sulfotransferase
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: ACID, HS6ST, CAN, HAD, Ndst1
Papers on 2-O-sulfotransferase
Proteoglycan expression correlates with the phenotype of malignant and non-malignant EBV-positive B-cell lines.
New
Grigorieva et al., Novosibirsk, Russia. In Oncotarget, Jan 2016
In this study, expression of major proteoglycans (syndecan-1, glypican-1, perlecan, versican, brevican, aggrecan, NG2, serglycin, decorin, biglycan, lumican, CD44), heparan sulphate (HS) metabolic system (EXT1/2, NDST1/2, GLCE, HS2ST1, HS3ST1/2, HS6ST1/2, SULF1/2, HPSE) and extracellular matrix (ECM) components (collagen 1A1, fibronectin, elastin) in primary B cells and EBV carrying cell lines with different phenotypes, patterns of EBV-host cell interaction and viral latency stages (type I-III) was investigated.
Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity.
New
Chang et al., Buffalo, United States. In Infect Immun, Sep 2015
Inactivation of heparan sulfate uronyl 2-O-sulfotransferase (Hs2st) in neutrophils substantially reduced their bactericidal activity, and Hs2st deficiency rendered mice more susceptible to systemic infection with the pathogenic bacterium group B Streptococcus.
C5-epimerase and 2-O-sulfotransferase associate in vitro to generate contiguous epimerized and 2-O-sulfated heparan sulfate domains.
New
Laguri et al., Grenoble, France. In Acs Chem Biol, May 2015
Using this new approach, we report that the association of C5-epimerase and 2-O-sulfotransferase, which catalyze the production of iduronic acid and its 2-O-sulfation, respectively, is necessary to processively generate extended sequences of contiguous IdoA2S-containing disaccharides, whereas modifications are randomly introduced when the enzymes are uncoupled.
High cell density cultivation of recombinant Escherichia coli strains expressing 2-O-sulfotransferase and C5-epimerase for the production of bioengineered heparin.
New
Zhang et al., Shanghai, China. In Appl Biochem Biotechnol, Mar 2015
One step in the current process to prepare bioengineered heparin involves the conversion of N-sulfo heparosan, rich in → 4)GlcNS(1 → 4) GlcA(1 → sequences (where S is sulfo, GlcN is α-D-glucosamine, and GlcA is β-D-glucuronic acid), to a critical intermediate, rich in → 4)GlcNS(1 → 4) IdoA2S(1 → sequences (where S is sulfo and IdoA is α-L-iduronic acid), using 2-O-sulfotransferase (2-OST) and C5 epimerase (C5-epi).
Uronyl 2-O sulfotransferase potentiates Fgf2-induced cell migration.
New
Seidler et al., In J Cell Sci, Mar 2015
Uronyl 2-O-sulfotransferase (Ust)introduces sulfation at the C2 of IdoUA and GlcUA resulting inover-sulfated units.
2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline.
Pratt et al., Edinburgh, United Kingdom. In Plos One, 2014
In mammals HS is subjected to differential sulfation by fifteen different heparan sulfotransferase (HST) enzymes of which Hs2st uniquely catalyzes the sulfation of the 2-O position of the uronate in HS.
Role of heparan sulfate proteoglycans in optic disc and stalk morphogenesis.
Zhang et al., Indianapolis, United States. In Dev Dyn, 2014
RESULTS: To study HSPG-dependent coordination of these signaling pathways during mammalian visual system development, we have generated a series of OV-specific mutations in the heparan sulfate (HS) N-sulfotransferase genes (Ndst1 and Ndst2) and HS O-sulfotransferase genes (Hs2st, Hs6st1, and Hs6st2) in mice.
A genomewide association study for average daily gain in Italian Large White pigs.
Russo et al., Bologna, Italy. In J Anim Sci, 2014
Two or more SNP targeted the same gene: IGSF3 and HS2ST1 (SSC4), OTOGL (SSC5), FTO region (SSC6), and MYLK4 and MCUR1 (SSC7).
Growth factor-heparan sulfate "switches" regulating stages of branching morphogenesis.
Review
Bush et al., San Diego, United States. In Pediatr Nephrol, 2014
Genetic deletions of HS biosynthetic enzymes (e.g., C5-epimerase, Hs2st), as well as considerable in vitro data, indicate that variably sulfated HS are essential for kidney development, particularly in Wolffian duct budding and early ureteric bud (UB) branching.
Combinatorial roles of heparan sulfate proteoglycans and heparan sulfates in Caenorhabditis elegans neural development.
Kinnunen, Huddersfield, United Kingdom. In Plos One, 2013
Genetic analyses suggest that syndecan/sdn-1 and HS 6-O-sulfotransferase, hst-6, function in a linear signaling pathway and glypican/lon-2 and HS 2-O-sulfotransferase, hst-2, function together in a pathway that is parallel to sdn-1 and hst-6.
Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice.
GeneRIF
Esko et al., San Diego, United States. In Blood, 2012
Inactivation of uronyl 2-O-sulfotransferase in endothelial cells (Hs2st), an enzyme that acts downstream from Ndst1, results in enhanced neutrophil recruitment in several models of acute inflammation.
Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance.
GeneRIF
Esko et al., San Diego, United States. In J Biol Chem, 2010
Plasma lipoprotein clearance depends on specific subclasses of sulfate groups and not on overall charge of the chains.
Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.
GeneRIF
Liu et al., Chapel Hill, United States. In J Biol Chem, 2007
analysis of differences and similarities various residues play in the biological roles of the HS-2OST and CS-2OST enzymes
Specific and flexible roles of heparan sulfate modifications in Drosophila FGF signaling.
GeneRIF
Nakato et al., Minneapolis, United States. In J Cell Biol, 2006
We found that mutations in Hs2st or Hs6st had unexpectedly little effect on tracheal morphogenesis. Structural analysis of mutant HS revealed not only a loss of corresponding sulfation, but also a compensatory increase of sulfation at other positions.
Heparan sulphation patterns generated by specific heparan sulfotransferase enzymes direct distinct aspects of retinal axon guidance at the optic chiasm.
GeneRIF
Mason et al., Edinburgh, United Kingdom. In J Neurosci, 2006
Hs2st and/or Hs6st1 expression coincides with Slit expression domains at locations where retinal ganglion cell(RGC) axons make navigation errors in Hs2st-/- and Hs6st1-/- mutants, and Hs6st1-/-RGC axons are less sensitive to Slit2 repulsion.
Role of heparan sulfate-2-O-sulfotransferase in the mouse.
Review
Wilson et al., Manchester, United Kingdom. In Biochim Biophys Acta, 2003
HS 2-O-sulfotransferase (Hs2st) occupies a critical position in the succession of enzymes responsible for the biosynthesis of HS, catalysing the transfer of sulfate to the C2-position of selected hexuronic acid residues within the nascent HS chain.
Heparan sulfate 2-O-sulfotransferase (Hs2st) and mouse development.
Review
GeneRIF
Merry et al., Edinburgh, United Kingdom. In Glycoconj J, 2002
The phenotype of Hs2st(-/-) mutant kidneys suggests that signalling between two tissues, ureteric bud and metanephric mesenchyme, is disrupted.
New insights into heparan sulphate biosynthesis from the study of mutant mice.
Review
Gallagher et al., Manchester, United Kingdom. In Biochem Soc Symp, 2001
In this discussion, we outline the key findings of these studies, and use them to put into context our own work concerning the structure of the HS generated by the Hs2st -/- mice.
Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting.
Review
Muramatsu, Nagoya, Japan. In J Biochem, 2000
Examples of abnormalities of null mutants include arrest of embryogenesis due to deletion of N-acetylglucosaminyltransferase I or glucosylceramide synthase, failure of kidney formation in heparan sulfate 2-O-sulfotransferase deficiency, suppressed antibody production in alpha-2, 6-sialyltransferase deficiency, male sterility in GM2/GD2 synthase deficiency, and abnormalities in the function and stability of myelin in galactosylceramide deficiency.
Spatially restricted expression of pipe in the Drosophila egg chamber defines embryonic dorsal-ventral polarity.
Impact
Stein et al., New York City, United States. In Cell, 1998
pipe, which encodes an enzyme similar to the glycosaminoglycan-modifying enzyme heparan sulfate 2-O-sulfotransferase, is expressed in a spatially restricted domain of follicle cells on the ventral side of the egg chamber.
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