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ATPase, H+ transporting, lysosomal accessory protein 1

16a, CF2
This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, V1a, fibrillin-1
Papers on 16a
Photomediated Controlled Radical Polymerization and Block Copolymerization of Vinylidene Fluoride.
Asandei, United States. In Chem Rev, Feb 2016
Finally, the rational selection of metal carbonyls that are successful not only as IDT mediators but, more importantly, in the quantitative activation of both PVDF-CH2-CF2-I and PVDF-CF2-CH2-I chain ends toward the synthesis of well-defined PVDF block copolymers is presented.
On the stability of manganese tris(β-diketonate) complexes as redox mediators in DSSCs.
Bignozzi et al., Ferrara, Italy. In Phys Chem Chem Phys, Feb 2016
UNASSIGNED: The photoelectrochemical properties and stability of dye sensitized solar cells containing Mn(β-diketonato)3 complexes, [Mn(III)(acac)3] () (acac = acetylacetonate), [Mn(III)(CF2)3] () (CF2 = 4,4-difluoro-1-phenylbutanate-1,3-dione), [Mn(III)(DBM)3] () (DBM = dibenzoylmethanate), [Mn(II)(CF2)3]TBA (TBA = tetrabutylammonium) () and [Mn(II)(DBM)3]TBA (), have been evaluated.
Atmospheric Degradation Initiated by OH Radicals of the Potential Foam Expansion Agent, CF3(CF2)2CH═CH2 (HFC-1447fz): Kinetics and Formation of Gaseous Products and Secondary Organic Aerosols.
Mellouki et al., Ciudad Real, Spain. In Environ Sci Technol, Feb 2016
UNASSIGNED: The assessment of the atmospheric impact of the potential foam expansion agent, CF3(CF2)2CH═CH2 (HFC-1447fz), requires the knowledge of its degradation routes, oxidation products, and radiative properties.
Carbon storage potential in size-density fractions from semi-natural grassland ecosystems with different productivities over varying soil depths.
Schulz et al., Halle, Germany. In Sci Total Environ, Jan 2016
Two clay-associated fractions (CF1, <1μm; and CF2, 1-2μm) and two light fractions (LF1, <1.8gcm(-3); and LF2, 1.8-2.0gcm(-3))
Characterization of Genomic Variants Associated with Scout and Recruit Behavioral Castes in Honey Bees Using Whole-Genome Sequencing.
Rodriguez-Zas et al., Beijing, China. In Plos One, Dec 2015
Most frequent putative transcription factor binding sites proximal to significant variants included Broad-complex 4, Broad-complex 1, Hunchback, and CF2-II.
Kinetics of the inhibition of renin and angiotensin I-converting enzyme by cod (Gadus morhua) protein hydrolysates and their antihypertensive effects in spontaneously hypertensive rats.
Aluko et al., Winnipeg, Canada. In Food Nutr Res, 2014
In order to enhance peptide activity, the CPH was subjected to reverse-phase (RP)-HPLC separation to yield four fractions (CF1, CF2, CF3, and CF4).
TMEM16A/B associated CaCC: structural and functional insights.
Zhan et al., Tianjin, China. In Protein Pept Lett, 2013
Transmembrane proteins 16A and 16B (TMEM16A/B) were identified to be the best molecular identities of CaCCs to date.
V-ATPase subunit ATP6AP1 (Ac45) regulates osteoclast differentiation, extracellular acidification, lysosomal trafficking, and protease exocytosis in osteoclast-mediated bone resorption.
Li et al., Birmingham, United States. In J Bone Miner Res, 2012
The essential role of Ac45 in osteoclast-mediated extracellular acidification and protease exocytosis, as well as the ability of Ac45 to guide lysosomal intracellular trafficking to the ruffled border, is demonstrated.
Mast cell restricted mouse and human tryptase·heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen.
Stevens et al., Boston, United States. In J Biol Chem, 2012
Mast cell restricted mouse and human tryptase.heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen.
Thrombomodulin domains attenuate atherosclerosis by inhibiting thrombin-induced endothelial cell activation.
Wu et al., Tainan City, Taiwan. In Cardiovasc Res, 2011
Recombinant thrombomodulin domains 2 and 3 protein significantly reduces atherosclerosis and neointima formation through its thrombin-binding ability.
Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica.
Smiley et al., United States. In J Immunol, 2011
Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica.
Versatile roles of V-ATPases accessory subunit Ac45 in osteoclast formation and function.
Zheng et al., Shanghai, China. In Plos One, 2010
propose that, in addition to its canonical function in V-ATPase-mediated acidification, Ac45 plays versatile roles during osteoclast formation and function.
Aztreonam lysine for inhalation solution: in cystic fibrosis.
Plosker, Auckland, New Zealand. In Drugs, 2010
Two phase III, randomized, placebo-controlled trials (AIR-CF1 and AIR-CF2) have been completed with AZLI in cystic fibrosis patients with pulmonary P. aeruginosa infection.
What's new in bullous pemphigoid.
Shimizu et al., Sapporo, Japan. In J Dermatol, 2010
The non-collagenous 16A domain of COL17 is considered to contain pathogenic epitopes of BP.
Nonporous organic solids capable of dynamically resolving mixtures of diiodoperfluoroalkanes.
Resnati et al., Milano, Italy. In Science, 2009
The process is highly selective for the fluorocarbon that forms an I-...I(CF2)mI...I- superanion that is matched in length to the chosen dication.
TMEM16A confers receptor-activated calcium-dependent chloride conductance.
Oh et al., Seoul, South Korea. In Nature, 2008
Here we show that transmembrane protein 16A (TMEM16A, which we also call anoctamin 1 (ANO1)) is a bona fide Ca(2+)-activated chloride channel that is activated by intracellular Ca(2+) and Ca(2+)-mobilizing stimuli.
Perfluoropolyethylene glycol–labeled BDC2.5 T cells
Zhang, Bethesda, United States. In Unknown Journal, 2008
The center CF2 groups can generate a strong peak (>0.9 at -92 ppm) that dominates 90% of its (19)F signal, whereas the end CF2 groups yield a weak signal (<0.1 at -79 ppm) that is below the in vivo MRI detection limit.
The pathophysiology of bullous pemphigoid.
Zillikens et al., Lübeck, Germany. In Clin Rev Allergy Immunol, 2007
Most BP patients have autoantibodies binding to an immunodominant region of BP180, the noncollagenous 16A domain (NC16A), which is located extracellularly close to the transmembrane domain of the protein.
Attaching the fluorine atom to organic molecules using BrF3 and other reagents directly derived from F2.
Rozen, Tel Aviv-Yafo, Israel. In Acc Chem Res, 2005
Elemental fluorine is a starting point for nucleophilic fluorinations (e.g., BrF3), radical fluorinations (e.g., F2 under irradiation), and electrophilic fluorinations (e.g., AcOF).
Isolation of two seven-membered ring C58 fullerene derivatives: C58F17CF3 and C58F18.
Taylor et al., Chernogolovka, Russia. In Science, 2005
The loss of carbon from C60 is believed to occur via sequential fluorine addition to a CC single bond and an adjacent CC bond, followed by loss of a:CF2 carbene.
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