GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Prostaglandin reductase 2
15-Oxoprostaglandin 13-Reductase, GPR142, PgR-2, prg-2
GPR142 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008] (from
NCBI)
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Top mentioned proteins:
CAN, GPR139, GPCR, ACID, Rhodopsin
Papers on
15-Oxoprostaglandin 13-Reductase
Comprehensive Profiling of GPCR Expression in Ghrelin-producing Cells.
New
Ōsaka, Japan. In Endocrinology, Jan 2016
In addition, GPR142 ligand tryptophan stimulated ghrelin secretion.
Boolean network model for GPR142 against Type 2 diabetes and relative dynamic change ratio analysis using systems and biological circuits approach.
New
India. In Syst Synth Biol, Jun 2015
In this paper, we report systems biology and biological circuits approach to construct pathway and identify early gene and protein interactions for predicting GPR142 responses in Type 2 diabetes.
Papillary renal cell carcinoma: a clinicopathological and whole-genome exon sequencing study.
Shihezi, China. In Int J Clin Exp Pathol, 2014
The missense mutation status of 19 genes differed significantly between the groups (P < 0.05), and alterations in the EEF1D, RFNG, GPR142, and RAB37 genes were located in different chromosomal regions in type 1 and 2 PRCC.
Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors.
India. In Mol Phylogenet Evol, 2014
Our study was able to identify potential ligand association for Class A Orphans and putative/unclassified Class A receptors with no cognate ligand information: GPR21 and GPR52 with fatty acids; GPR75 with Neuropeptide Y; GPR82, GPR18, GPR141 with N-arachidonylglycine; GPR176 with Free fatty acids, GPR10 with Tachykinin & Neuropeptide Y; GPR85 with ATP, ADP & UDP glucose; GPR151 with Galanin; GPR153 and GPR162 with Adrenalin, Noradrenalin; GPR146, GPR139, GPR142 with Neuromedin, Ghrelin, Neuromedin U-25 & Thyrotropin-releasing hormone; GPR171 with ATP, ADP & UDP Glucose; GPR88, GPR135, GPR161, GPR101with 11-cis-retinal; GPR83 with Tackykinin; GPR148 with Prostanoids, GPR109b, GPR81, GPR31with ATP & UTP and GPR150 with GnRH I & GnRHII.
Aminopyrazole-Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies.
San Francisco, United States. In Acs Med Chem Lett, 2013
Herein, we report the lead optimization of amrinone-phenylalanine based GPR142 agonists.
Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes.
Tokyo, Japan. In Acs Med Chem Lett, 2013
GPR142 is a G protein-coupled receptor that is predominantly expressed in pancreatic β-cells.
Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes.
San Francisco, United States. In Bioorg Med Chem Lett, 2012
GPR142 is a novel GPCR that is predominantly expressed in pancreatic β-cells.
Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus.
San Francisco, United States. In Bioorg Med Chem Lett, 2012
The discovery and initial optimization of a series of phenylalanine based agonists for GPR142 is described.
Identification of surrogate agonists and antagonists for orphan G-protein-coupled receptor GPR139.
The Woodlands, United States. In J Biomol Screen, 2009
This compound increased cAMP production specifically in cells expressing GPR139 but not in cells expressing its highly homologous receptor GPR142.
Differentiated expression of estrogen receptors (ER) and progesterone receptors (PgR) in ductal breast cancers.
Wrocław, Poland. In Folia Histochem Cytobiol, 2008
From every tumour three samples were taken for immunohistochemical studies: the lateral one from the side of axilla (ER-1; PgR-1); the median one (ER-2; PgR-2) and the medial one from the side of sternum (ER-3; PgR-3).
A C. elegans Piwi, PRG-1, regulates 21U-RNAs during spermatogenesis.
New Haven, United States. In Curr Biol, 2008
C. elegans contains a large set of Argonaute/Piwi-related proteins, including two closely related to piwi called prg-1 and prg-2.
A high throughput live transparent animal bioassay to identify non-toxic small molecules or genes that regulate vertebrate fat metabolism for obesity drug development.
Cincinnati, United States. In Nutr Metab (lond), 2007
Results from knockdown of a zebrafish G-PCR ortholog previously determined to decrease fat content in C. elegans support that future GPR142 antagonists may be effective non-toxic anti-obesity therapeutics.
Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation.
GeneRIF
Taipei, Taiwan. In J Biol Chem, 2007
15-oxoprostaglandin-Delta13-reductase (PGR-2) catalyzes the reaction converting 15-keto-PGE2 to 13,14-dihydro-15-keto-PGE2
Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development.
GeneRIF
Hamburg, Germany. In Neuropharmacology, 2006
GPR142 mRNA showed a ubiquitous expression both in the brain and in various peripheral glands and organs in pre- and postnatal development.
Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2.10 A resolution.
GeneRIF
Menlo Park, United States. In Proteins, 2004
This mouse gene encodes a putative NADPH-dependent oxidoreductase. We report the crystal structure of the putative oxidoreductase determined by the semi-automated high-throughput pipeline of the Joint Center for Structural Genomics
Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives.
Uppsala, Sweden. In Febs Lett, 2003
We report seven new members of the superfamily of human G protein-coupled receptors (GPCRs) found by searches in the human genome databases, termed GPR100, GPR119, GPR120, GPR135, GPR136, GPR141, and GPR142.
