15-Lipoxygenase inhibitors: a patent review.
Mashhad, Iran. In Expert Opin Ther Pat, Dec 2015
Two types of the enzyme, 15-LOX-1 and 15-LOX-2, have been recognized in mammals to have different abilities in the peroxidation of arachidonic acid and linoleic acid.
Expression microarray as a tool to identify differentially expressed genes in horses suffering from inflammatory airway disease.
Liège, Belgium. In Vet Clin Pathol, Mar 2015
These genes were related to inflammation (eg, ALOX15B, PLA2G12B, and PENK), oxidant/antioxidant balance (eg, DUOXA2 and GSTO1-1), and stress (eg, V1aR, GRLF1, Homer-2, and MAOB).
Leukotriene signaling in the extinct human subspecies Homo denisovan and Homo neanderthalensis. Structural and functional comparison with Homo sapiens.
Berlin, Germany. In Arch Biochem Biophys, 2015
For this study we extracted the nucleotide sequences of selected eicosanoid relevant genes (ALOX5, ALOX15, ALOX12, ALOX15B, ALOX12B, ALOXE3, COX1, COX2, LTA4H, LTC4S, ALOX5AP, CYSLTR1, CYSLTR2, BLTR1, BLTR2) from the corresponding databases.
Discovery of ML351, a Potent and Selective Inhibitor of Human 15-Lipoxygenase-1
Bethesda, United States. In Unknown Journal, 2013
Toward this end, we employed a quantitative high-throughput (qHTS) screen against ∼74,000 small molecules which led to the discovery of ML351, a novel chemotype for 15-LOX-1 inhibition, that displays nanomolar potency (IC50 = 200 nM) and excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2.