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Arachidonate 15-lipoxygenase, type B

15-LOX-2, 15-lipoxygenase-2, 15S-lipoxygenase, ALOX15B
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: lysyl oxidase, ACID, Arachidonate 15-Lipoxygenase, LOX-1, 5-lipoxygenase
Papers using 15-LOX-2 antibodies
Inflammatory angiogenesis in atherogenesis–a double-edged sword
Supplier
Schulz Christian, In PLoS ONE, 2007
... ALOX15B siRNA (Qiagen, SI03076206) or nonsilencing control ...
Papers on 15-LOX-2
Identification of miRNAs and differentially expressed genes in early phase non-small cell lung cancer.
New
Yuan et al., Cangzhou, China. In Oncol Rep, Feb 2016
Genes S100P, ALOX15B, CCL11, NLRP2, SERPINA3, FoxO4 and hsa-miR-491 may play important roles in the development of early-stage NSCLC.
The role of lipoxygenases in pathophysiology; new insights and future perspectives.
Review
New
Okuyama et al., Tokyo, Japan. In Redox Biol, Dec 2015
15-LOX-2, which is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice, therefore, the role of them in mammals has not been established.
15-Lipoxygenase inhibitors: a patent review.
New
Jabbari et al., Mashhad, Iran. In Expert Opin Ther Pat, Dec 2015
Two types of the enzyme, 15-LOX-1 and 15-LOX-2, have been recognized in mammals to have different abilities in the peroxidation of arachidonic acid and linoleic acid.
Probing the range of applicability of structure- and energy-adjusted QM/MM link bonds.
New
Hofer et al., Innsbruck, Austria. In J Comput Chem, Nov 2015
Furthermore, the scope and range of the perturbation, stemming from the introduction of link bonds is evaluated through application of the presented QM/MM scheme in calculations of the active site of 15S-lipoxygenase.
Antineoplastic effects of 15(S)-hydroxyeicosatetraenoic acid and 13-S-hydroxyoctadecadienoic acid in non-small cell lung cancer.
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Chen et al., Hong Kong, Hong Kong. In Cancer, Oct 2015
BACKGROUND: Previous studies have shown that the levels of 15-lipoxygenase 1 (15-LOX-1) and 15-LOX-2 as well as their metabolites 13-S-hydroxyoctadecadienoic acid (13(S)-HODE) and 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) are significantly reduced in smokers with non-small cell lung carcinoma (NSCLC).
15-Lipoxygenases regulate the production of chemokines in human lung macrophages.
New
Devillier et al., Suresnes, France. In Br J Pharmacol, Sep 2015
Levels of ALOX15 (15-LOX-1) and ALOX15B (15-LOX-2) transcripts were determined by real-time quantitative PCR.
Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase.
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Holman et al., Santiago, Chile. In Chem Biol Drug Des, Jul 2015
Of the 26 compounds tested, 10 isoflavones and 9 isoflavans possessed micromolar potency, but only three were selective against 5-LOX (IR-2, HIR-303, and HIR-309), with IC50 values at least 10 times lower than those of 12-LOX, 15-LOX-1, and 15-LOX-2.
Expression microarray as a tool to identify differentially expressed genes in horses suffering from inflammatory airway disease.
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Lekeux et al., Liège, Belgium. In Vet Clin Pathol, Mar 2015
These genes were related to inflammation (eg, ALOX15B, PLA2G12B, and PENK), oxidant/antioxidant balance (eg, DUOXA2 and GSTO1-1), and stress (eg, V1aR, GRLF1, Homer-2, and MAOB).
12/15 Lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models.
New
Zhang et al., Nashville, United States. In Oncotarget, Mar 2015
Human 15-lipoxygenase 1 (15-LOX-1) converts LA to anti-tumor 13-S-hydroxyoctadecadienoic acid (13-HODE)and 15-LOX-2 converts AA to 15-hydroxyeicosatetraenoic acid (15-HETE).
Leukotriene signaling in the extinct human subspecies Homo denisovan and Homo neanderthalensis. Structural and functional comparison with Homo sapiens.
Heydeck et al., Berlin, Germany. In Arch Biochem Biophys, 2015
For this study we extracted the nucleotide sequences of selected eicosanoid relevant genes (ALOX5, ALOX15, ALOX12, ALOX15B, ALOX12B, ALOXE3, COX1, COX2, LTA4H, LTC4S, ALOX5AP, CYSLTR1, CYSLTR2, BLTR1, BLTR2) from the corresponding databases.
Modulation of Pulmonary Vascular Remodeling in Hypoxia: Role of 15-LOX-2/15-HETE-MAPKs Pathway.
Zhu et al., Daqing, China. In Cell Physiol Biochem, 2014
The purpose of this study was to investigate the role of 15-lipoxygenase-2 (15-LO-2)/15-HETE-mitogen-activated protein kinases (MAPKs) pathway in hypoxia-induced pulmonary vascular remodeling and the underlying mechanisms.
Discovery of ML351, a Potent and Selective Inhibitor of Human 15-Lipoxygenase-1
Review
Maloney et al., Bethesda, United States. In Unknown Journal, 2013
Toward this end, we employed a quantitative high-throughput (qHTS) screen against ∼74,000 small molecules which led to the discovery of ML351, a novel chemotype for 15-LOX-1 inhibition, that displays nanomolar potency (IC50 = 200 nM) and excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2.
Platelet-derived growth factor (PDGF) induces pulmonary vascular remodeling through 15-LO/15-HETE pathway under hypoxic condition.
GeneRIF
Zhu et al., Daqing, China. In Cell Signal, 2012
Hypoxia promotes pulmonary artery smooth muscle cell proliferation and survival, contributing to pulmonary vascular medial hypertrophy, which is likely to be mediated via the PDGF-BB/15-LO-2/15-HETE pathway.
Preeclampsia activates 15-lipoxygenase and its metabolite 15-hydroxyeicosatetraenoic acid enhances constriction in umbilical arteries.
GeneRIF
Zheng et al., Harbin, China. In Prostaglandins Leukot Essent Fatty Acids, 2012
Data indicate that expressions of 15-LO-1 and 15-LO-2 in placentas and umbilical artery (HUA) rings in preeclampsia (PE) increased more than that in normal groups.
The N-terminal β-barrel domain of mammalian lipoxygenases including mouse 5-lipoxygenase is not essential for catalytic activity and membrane binding but exhibits regulatory functions.
GeneRIF
Kühn et al., Berlin, Germany. In Arch Biochem Biophys, 2012
The C2-domain is not essential for catalytic activity and does hardly impact reaction specificity.
Tumor-associated macrophages mediate immunosuppression in the renal cancer microenvironment by activating the 15-lipoxygenase-2 pathway.
GeneRIF
Kusmartsev et al., Gainesville, United States. In Cancer Res, 2011
Tumor-associated macrophages isolated from RCC tumors had a high 15-LOX2 expression and secreted substantial amounts of 15(S)-hydroxyeicosatetraenoic acid.
12- and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms.
GeneRIF
Gabrielsen et al., Stockholm, Sweden. In Atherosclerosis, 2011
In summary, we observed associations between high ALOX15B expression in carotid lesions and a history of cerebrovascular symptoms.
Lipoxygenase metabolism: roles in tumor progression and survival.
Review
Honn et al., Dublin, Ireland. In Cancer Metastasis Rev, 2007
5-LOX and platelet type 12-LOX are generally considered pro-carcinogenic, with the role of 15-LOX-1 remaining controversial, while 15-LOX-2 suppresses carcinogenesis.
15-lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size).
Review
Schneider-Broussard et al., United States. In Prostaglandins Other Lipid Mediat, 2007
15-Lipoxygenase 2 (15-LOX2) is the major mammalian lipoxygenase expressed in normal human adult prostate and its expression is decreased or lost in high-grade prostate intraepithelial neoplasia (HGPIN) and prostate cancer (PCa).
Arachidonate 8(S)-lipoxygenase.
Review
Krieg et al., Heidelberg, Germany. In Prostaglandins Other Lipid Mediat, 2002
The 8(S)-lipoxygenase gene, Alox15b, consisting of 14 exons and spanning 14.5 kb is located within a gene cluster of related epidermis-type lipoxygenases at the central region of mouse chromosome 11.
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