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Hydroxyprostaglandin dehydrogenase 15-

15-hydroxyprostaglandin dehydrogenase, PGDH, 15-PGDH
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] (from NCBI)
Papers on 15-hydroxyprostaglandin dehydrogenase
β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells.
Paraskeva et al., Bristol, United Kingdom. In Gut, 2012
beta-catenin has a novel role in promoting colorectal tumorigenesis through very early 15-PGDH suppression leading to increased PGE(2) levels, possibly even before COX-2 upregulation.
15-PGDH is reduced and induces apoptosis and cell cycle arrest in gastric carcinoma.
Wu et al., Shanghai, China. In World J Gastroenterol, 2012
Data suggest that reduction of 15-PGDH is associated with carcinogenesis and development of gastric carcinoma.
15-Hydroxyprostaglandin dehydrogenase associates with poor prognosis in breast cancer, induces epithelial-mesenchymal transition, and promotes cell migration in cultured breast cancer cells.
Iljin et al., Turku, Finland. In J Pathol, 2012
Our results indicate that HPGD is highly expressed in metastatic and aggressive breast cancer and promotes epithelial-mesenchymal transition and migration in breast cancer cells.
Protein tyrosine nitration of 15-hydroxy prostaglandin dehydrogenase in the human mast cell line LAD2.
Befus et al., Edmonton, Canada. In Nitric Oxide, 2012
protein tyrosine nitration of 15-hydroxy prostaglandin dehydrogenase in the human mast cells
15-hydroxyprostaglandin dehydrogenase is downregulated and exhibits tumor suppressor activity in gastric cancer.
Kim et al., Seoul, South Korea. In Cancer Invest, 2011
Demonstrate both downregulation and a tumor suppressor activity of 15-PGDH in gastric cancer.
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