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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Phosphohistidine phosphatase 1

14-kDa phosphohistidine phosphatase, PHPT1, phosphohistidine phosphatase, Phosphohistidine phosphatase 1, phosphohistidine phosphatase PHPT1, PHP14
PHPT1 is an EDTA-insensitive phosphohistidine phosphatase that catalyzes the dephosphorylation of phosphopeptide I (Ek et al., 2002 [PubMed 12383260]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, 14-kDa, TRPV5
Papers on 14-kDa phosphohistidine phosphatase
Chemical Synthesis of Proteins with Non-Strategically Placed Cysteines Using Selenazolidine and Selective Deselenization.
Metanis et al., Jerusalem, Israel. In Angew Chem Int Ed Engl, Jan 2016
The challenging protein, 125-residue human phosphohistidine phosphatase 1 (PHPT1), has three cysteines near the C-terminus, which are not strategically placed for ligation.
Nuclear expression and clinical significance of phosphohistidine phosphatase 1 in clear-cell renal cell carcinoma.
Tian et al., Beijing, China. In J Int Med Res, Dec 2015
OBJECTIVE: To explore expression and clinical relevance of phosphohistidine phosphatase 1 (PHPT1) in clear-cell renal cell carcinoma.
Phosphohistidine phosphatase 1 (PHPT1) also dephosphorylates phospholysine of chemically phosphorylated histone H1 and polylysine.
Zetterqvist et al., Uppsala, Sweden. In Ups J Med Sci, Mar 2015
BACKGROUND: Phosphohistidine phosphatase 1 (PHPT1), also named protein histidine phosphatase (PHP), is a eukaryotic enzyme dephosphorylating proteins and peptides that are phosphorylated on a histidine residue.
Nucleoside diphosphate kinase as protein histidine kinase.
Wieland et al., Crawley, United Kingdom. In Naunyn Schmiedebergs Arch Pharmacol, Feb 2015
In all three proteins, the phosphorylation of a specific histidine residue is of regulatory importance for protein function, and these phosphohistidines are cleaved by a counteracting 14 kDa phosphohistidine phosphatase (PHP).
Multipronged quantitative proteomic analyses indicate modulation of various signal transduction pathways in human meningiomas.
Srivastava et al., Mumbai, India. In Proteomics, 2015
Quite a few candidates, such as protein S-100A6, aldehyde dehydrogenase mitochondrial, AHNAK, cytoskeleton-associated protein 4, and caveolin, showed sequential increase in low- and high-grade MGs, whereas differential expressions of collagen alpha-1 (VI), protein S100-A9, 14 kDa phosphohistidine phosphatase, or transgelin-2 were found to be grade specific.
A splice variant of the human phosphohistidine phosphatase 1 (PHPT1) is degraded by the proteasome.
Bjerling et al., Uppsala, Sweden. In Int J Biochem Cell Biol, 2014
Nevertheless, there is a 14 kDa enzyme with phosphohistidine phosphatase activity, named PHPT1, found in most animals, but not in bacteria, plant or fungi.
Alterations in reversible protein histidine phosphorylation as intracellular signals in cardiovascular disease.
Attwood et al., Mannheim, Germany. In Front Pharmacol, 2014
More recently, it has become evident that the nucleoside diphosphate kinase isoform B (NDPK-B), an ubiquitously expressed enzyme involved in nucleotide metabolism, and a highly specific phosphohistidine phosphatase (PHP) form a regulatory histidine protein kinase/phosphatase system in mammals.
Regulation of the epithelial Ca²⁺ channel TRPV5 by reversible histidine phosphorylation mediated by NDPK-B and PHPT1.
Skolnik et al., New York City, United States. In Mol Biol Cell, 2014
The kidney, together with bone and intestine, plays a crucial role in maintaining whole-body calcium (Ca(2+)) homoeostasis, which is primarily mediated by altering the reabsorption of Ca(2+) filtered by the glomerulus.
14-kDa Phosphohistidine phosphatase plays an important role in hepatocellular carcinoma cell proliferation.
Zhu et al., Xi'an, China. In Oncol Lett, 2012
14-kDa Phosphohistidine phosphatase (PHP14), the first histidine phosphatase protein identified in vertebrates, was recently revealed to play an essential role in lung cancer.
[Study on gene differential expressions of substance and energy metabolism in chronic superficial gastritis patients of Pi deficiency syndrome and of pi-wei hygropyrexia syndrome].
Wang et al., Guangzhou, China. In Zhongguo Zhong Xi Yi Jie He Za Zhi, 2012
Genes correlated to protein metabolism included ASRGL1, AARSD1, EBNA1BP2, PUM2, MRPL52, C120RF65, PSMB8, PSME2, UBA7, RNF11, FBXO44, ZFYVE26, CHMP2A, SSR4, SNX4, RAB3B, RABL2A, GOLGA2, KDELR1, PHPT1, ACPP, PTPRF, CRKL, HDAC7, ADPRHL2, B3GNT1, ST8SIA4, DDOST, and FUT9, mainly involved in the biosynthesis processes of protein, ubiquitination, targeted transport and post-translation modification.
Influence of protein histidine phosphatase overexpression and down-regulation on human umbilical-vein endothelial cell viability.
Krieglstein et al., Münster, Germany. In Cell Biol Int, 2012
Overexpression of PHP by the use of a plasmid vector, pIRES2-AcGFP1-PHP, induced apoptosis in HUVEC
Arabitol metabolism of Corynebacterium glutamicum and its regulation by AtlR.
Eikmanns et al., Ulm, Germany. In J Bacteriol, 2012
Four of these genes are located in the direct vicinity of the atlR gene, i.e., xylB, rbtT, mtlD, and sixA, annotated as encoding xylulokinase, the ribitol transporter, mannitol 2-dehydrogenase, and phosphohistidine phosphatase, respectively.
Design and synthesis of an Fmoc-SPPS-compatible amino acid building block mimicking the transition state of phosphohistidine phosphatase.
Hedberg et al., Dortmund, Germany. In J Org Chem, 2012
The peptides are designed as inhibitors of phosphohistidine phosphatase and as a pull-down probe for identification of phosphohistidine phosphatases, respectively.
A screening method for phosphohistidine phosphatase 1 activity.
Ek et al., Uppsala, Sweden. In Ups J Med Sci, 2011
Therefore a screening method was developed primarily for the analysis of phosphohistidine phosphatase 1 (PHPT1) activity.
Clinical significance of PHPT1 protein expression in lung cancer.
Gu et al., Beijing, China. In Chin Med J (engl), 2010
Significantly higher expression levels of PHPT1 protein were found in lung cancer samples than in normal tissues adjacent to lung cancer.
Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells.
Kowluru et al., Detroit, United States. In Am J Physiol Endocrinol Metab, 2010
these data implicate regulatory roles for PHPT1 in a G protein-sensitive step involved in nutrient-induced insulin secretion
14-kDa phosphohistidine phosphatase and its role in human lung cancer cell migration and invasion.
He et al., Beijing, China. In Lung Cancer, 2010
These results demonstrate for the first time that PHP14 may be functionally important in lung cancer cell migration and the invasion of lung cancer cells, mediated partly through modulation of actin cytoskeleton rearrangement.
Reversible histidine phosphorylation in mammalian cells: a teeter-totter formed by nucleoside diphosphate kinase and protein histidine phosphatase 1.
Klumpp et al., Mannheim, Germany. In Methods Enzymol, 2009
The β subunit of heterotrimeric G proteins, the metabolic enzyme adenosine 5'-triphosphate-citrate lyase (ACL), and the Ca2+-activated K+ channel KCa3.1 have been identified as targets for nucleoside diphosphate kinase (NDPK) acting as protein histidine kinase and the so far only identified mammalian protein histidine phosphatase (PHPT-1).
Role of protein histidine phosphatase for viability of neuronal cells.
Krieglstein et al., Münster, Germany. In Brain Res, 2009
results suggest that an increased activity of protein histidine phosphatase (PHP) impairs neuron cellular function whereas downregulation of PHP does not
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