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Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

14-3-3zeta, YWHAZ
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Papers on 14-3-3zeta
Impairment of GABAB receptor dimer by endogenous 14-3-3ζ in chronic pain conditions.
Landry et al., Bordeaux, France. In Embo J, 2012
In the dorsal spinal cord of neuropathic rats, 14-3-3zeta is overexpressed and weakens GABAB inhibition.
Cofilin weakly interacts with 14-3-3 and therefore can only indirectly participate in regulation of cell motility by small heat shock protein HspB6 (Hsp20).
Gusev et al., Moscow, Russia. In Arch Biochem Biophys, 2012
cofilins 1 and 2 only weakly interact with 14-3-3 and therefore cannot directly compete with phosphorylated small heat shock protein HspB6 for its binding to 14-3-3 zeta
Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency.
Schwarz et al., Adelaide, Australia. In Mol Psychiatry, 2012
data provide the first evidence of a direct role for 14-3-3 zeta deficiency in the aetiology of neurodevelopmental disorders andas a central risk factor in schizophrenia.
Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription.
Ron et al., San Francisco, United States. In J Biol Chem, 2012
the function of nuclear RACK1 is mediated through its interaction with 14-3-3zeta
14-3-3ζ interacts with stat3 and regulates its constitutive activation in multiple myeloma cells.
Ge et al., Wuhan, China. In Plos One, 2011
Findings show that multiple signaling events impinge on Stat3 and that 14-3-3zeta serves as an essential coordinator for different pathways to regulate Stat3 activation and function in multiple myeloma cells.
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