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Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide

14-3-3eta, YWHAH
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009] (from NCBI)
Top mentioned proteins: endothelin receptor, OUT, CAN, 14-3-3zeta, Vps34
Papers on 14-3-3eta
Genetic variants in cell cycle control pathway confer susceptibility to aggressive prostate carcinoma.
Daw et al., Saint Louis, United States. In Prostate, Jan 2016
RESULTS: Eleven variants within 10 genes (CCNC, CCND3, CCNG1, CCNT2, CDK6, MDM2, SKP2, WEE1, YWHAB, YWHAH) in the European-American population and nine variants in 7 genes (CCNG1, CDK2, CDK5, MDM2, RB1, SMAD3, TERF2) in the African-American population were found to be associated with aggressive PCa using at least one model.
Changes in Brain 14-3-3 Proteins in Response to Insulin Resistance Induced by a High Palatable Diet.
Saraiva-Pereira et al., Porto Alegre, Brazil. In Mol Neurobiol, Aug 2015
Significant decrease was observed in Ywhah and in Ywahq mRNA levels in the cortex of IR group, while no changes were observed in the hippocampus.
Autoantibody Profiling of Glioma Serum Samples to Identify Biomarkers Using Human Proteome Arrays.
Srivastava et al., Mumbai, India. In Sci Rep, 2014
On a comparison of these two cohorts, we found STUB1 and YWHAH proteins dysregulated in Grade II glioma patients.
Genome-wide linkage analysis and association study identifies loci for polydactyly in chickens.
Wen et al., China. In G3 (bethesda), 2014
Of the identified SNPs, the eight nearest genes were sonic hedgehog (SHH), limb region 1 homolog (mouse) (LMBR1), dipeptidyl-peptidase 6, transcript variant 3 (DPP6), thyroid-stimulating hormone, beta (TSHB), sal-like 4 (Drosophila) (SALL4), par-6 partitioning defective 6 homolog beta (Caenorhabditis elegans) (PARD6B), coenzyme Q5 (COQ5), and tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, etapolypeptide (YWHAH).
Combined analysis of exon splicing and genome wide polymorphism data predict schizophrenia risk loci.
Scott et al., Newcastle, Australia. In J Psychiatr Res, 2014
We identified a number of significantly associated loci with a biologically plausible role in schizophrenia, including MCPH1, DLG3, ZC3H13, and BICD2, and additional loci that influence splicing of these genes, including YWHAH.
microRNA-320/RUNX2 axis regulates adipocytic differentiation of human mesenchymal (skeletal) stem cells.
Alajez et al., Riyadh, Saudi Arabia. In Cell Death Dis, 2013
Integrated analysis of bioinformatics and global gene expression profiling in miR-320c overexpressing cells and during adipocytic differentiation of hMSC identified several biologically relevant gene targets for miR-320c including RUNX2, MIB1 (mindbomb E3 ubiquitin protein ligase 1), PAX6 (paired box 6), YWHAH and ZWILCH.
Evidence for the requirement of 14-3-3eta (YWHAH) in meiotic spindle assembly during mouse oocyte maturation.
Kline et al., Kent, United States. In Bmc Dev Biol, 2012
We previously reported that all seven mammalian 14-3-3 isoforms are expressed in mouse oocytes and eggs and that, 14-3-3η (YWHAH) accumulates and co-localizes in the region of meiotic spindle in mouse eggs matured in vivo.
A systems biology approach to identify the signalling network regulated by Rho-GDI-γ during neural stem cell differentiation.
Wen et al., Shanghai, China. In Mol Biosyst, 2012
In particular, one randomly selected pathway involving Vcp, Mapk8, Ywhae and Ywhah was experimentally verified to be regulated by Rho-GDI-γ.
A polymorphism in the YWHAH gene encoding 14-3-3 eta that is not associated with sporadic Creutzfeldt-Jakob disease (CJD).
Kim et al., Anyang, South Korea. In Mol Biol Rep, 2012
This is the first genetic association study of YWHAH with sporadic Creutzfeldt-Jakob disease populations.
JAK-STAT and AKT pathway-coupled genes in erythroid progenitor cells through ontogeny.
Schechter et al., Belgrade, Serbia. In J Transl Med, 2011
Beside the continuously upregulated (AKT1, PPP2CA, CHUK, NFKB1) and downregulated (FOXO1, PDPK1, PIK3CG) genes in the PI3K-AKT signaling pathway, we also observed intermittently regulated gene expression (NFKBIA, YWHAH).
Dermal fibroblasts influence the expression profile of 14-3-3 proteins in human keratinocytes.
Ghahary et al., Vancouver, Canada. In Mol Cell Biochem, 2011
Data indicate that gene analysis revealed an up-regulation of all four 14-3-3 isoforms beta, eta, gamma, and sigma.
Meta-analysis of heterogeneous data sources for genome-scale identification of risk genes in complex phenotypes.
Brunak et al., Denmark. In Genet Epidemiol, 2011
We validate one such candidate experimentally, YWHAH, by genotyping five variations in 640 patients and 1,377 controls.
Cytoplasmic expression of p33ING1b is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma.
Takano et al., Yokohama, Japan. In Histol Histopathol, 2011
relocation of p33ING1b from the nucleus to the cytoplasm, where the protein is tethered by 14-3-3eta, participates in tumorigenesis and progression in HNSCC
14-3-3 η inhibits chondrogenic differentiation of ATDC5 cell.
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2011
14-3-3 eta plays a regulatory role in chondrogenic differentiation.
Depletion of 14-3-3 protein exacerbates cardiac oxidative stress, inflammation and remodeling process via modulation of MAPK/NF-ĸB signaling pathways after streptozotocin-induced diabetes mellitus.
Watanabe et al., Niigata, Japan. In Cell Physiol Biochem, 2010
The myocardial NF-kappaB activation, inhibitor of kappa B-alpha degradation and mRNA expression of proinflammatory cytokines were significantly increased in DN 14-3-3 mice compared to WT mice.(14-3-3 protein eta)
Family-based association of YWHAH in psychotic bipolar disorder.
Potash et al., Baltimore, United States. In Am J Med Genet B Neuropsychiatr Genet, 2009
The association of YWHAH with bipolar disorder in a large sample, consisting of 1211 subjects from 318 nuclear families including 554 affected offspring, was investigated.
Heterogeneous in vitro effects of doxorubicin on gene expression in primary human liposarcoma cultures.
Lehnhardt et al., Bochum, Germany. In Bmc Cancer, 2007
The pro-apoptotic CD14, TIA1, and ITGB2 were down-regulated in more than 50% of the tumor cultures after treatment with doxorubicin, as was the antiapoptotic YWHAH.
eIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia?
Carter, In Schizophr Bull, 2007
These include NMDA (GRIN1, GRIN2A, GRIN2B) and metabotropic (GRM3, GRM4) glutamate receptors, growth factors (BDNF, NRG1), and many of their downstream signaling components or accomplices (AKT1, DAO, DAOA, DISC1, DTNBP1, DPYSL2, IMPA2, NCAM1, NOS1, NOS1AP, PIK3C3, PIP5K2A, PDLIM5, RGS4, YWHAH).
Increases in expression of 14-3-3 eta and 14-3-3 zeta transcripts during neuroprotection induced by delta9-tetrahydrocannabinol in AF5 cells.
Freed et al., Baltimore, United States. In J Neurosci Res, 2007
These data suggest that increases in 14-3-3 proteins mediate THC-induced neuroprotection under conditions of NMDA-induced cellular stress.
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