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Hydroxysteroid 11-beta dehydrogenase 1

11 beta-hydroxysteroid dehydrogenase, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-HSD1
catalyzes the interconversion of cortisol and cortisone; plays a role in glucocorticoid metabolism; may regulate blood pressure [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Inactive, Insulin, HAD, ACID, CAN
Papers on 11 beta-hydroxysteroid dehydrogenase
Loss of 11βHSD1 enhances glycolysis, facilitates intrahepatic metastasis, and indicates poor prognosis in hepatocellular carcinoma.
New
Chen et al., Wuhan, China. In Oncotarget, Jan 2016
UNASSIGNED: 11Beta-hydroxysteroid dehydrogenase type 1 (11βHSD1), converting glucocorticoids from hormonally inactive cortisone to active cortisol, plays an essential role in glucose homeostasis.
Higher glucocorticoid secretion in the physiological range is associated with lower bone strength at the proximal radius in healthy children: importance of protein intake adjustment.
New
Remer et al., Dortmund, Germany. In J Bone Miner Res, Feb 2015
UFF + UFE, UFE itself, and a urinary metabolite-estimate of 11beta-hydroxysteroid dehydrogenase type1 (11beta-HSD1) activity showed corresponding reciprocal associations (p < 0.05) with BMD and bone mineral content, but not with SSI and bone geometry variables.
Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice.
Seckl et al., Edinburgh, United Kingdom. In Neurobiol Aging, 2015
11Beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) locally amplifies active glucocorticoids within specific tissues including in brain.
Momordica charantia ameliorates insulin resistance and dyslipidemia with altered hepatic glucose production and fatty acid synthesis and AMPK phosphorylation in high-fat-fed mice.
Wu et al., Taiwan. In Phytother Res, 2014
Most importantly, MCE decreased expression of hepatic 11beta hydroxysteroid dehydroxygenase (11beta-HSD1) gene, which contributed in attenuating diabetic state.
β-Cell-Specific Glucocorticoid Reactivation Attenuates Inflammatory β-Cell Destruction.
Morton et al., Edinburgh, United Kingdom. In Front Endocrinol (lausanne), 2013
Here, we tested the hypothesis that elevated β-cell 11beta-HSD1 protects against the β-cell destruction elicited by streptozotocin (STZ), a toxin that dose-dependently mimics aspects of inflammatory and autoimmune β-cell destruction.
Fructose consumption enhances glucocorticoid action in rat visceral adipose tissue.
Matić et al., Belgrade, Serbia. In J Nutr Biochem, 2013
There is evidence that enhanced glucocorticoid regeneration within adipose tissue, mediated by the enzyme 11beta-hydroxysteroid dehydrogenase Type 1 (11βHSD1), may contribute to adiposity and metabolic disease.
11beta-Hydroxysteroid dehydrogenase type 1 inhibitors: novel agents for the treatment of metabolic syndrome and obesity-related disorders?
Review
Mikhailidis et al., Thessaloníki, Greece. In Metabolism, 2013
OBJECTIVE: Metabolic syndrome (MetS) and Cushing's syndrome share common features.
Piper sarmentosum is comparable to glycyrrhizic acid in reducing visceral fat deposition in adrenalectomised rats given dexamethasone.
Farihah et al., Kuala Lumpur, Malaysia. In Clin Ter, 2012
In adipose tissue, the enzyme 11beta-hydroxysteroid dehydrogenase type 1 regulates cortisol metabolism (11beta-HSD1).
Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1.
GeneRIF
Stewart et al., Birmingham, United Kingdom. In Endocrinology, 2012
mice with liver-specific disruption of 11beta-hydroxysteroid dehydrogenase type 1 lack significant metabolic abnormalities
Ubiquitin-specific protease 2 regulates hepatic gluconeogenesis and diurnal glucose metabolism through 11β-hydroxysteroid dehydrogenase 1.
GeneRIF
Lin et al., Ann Arbor, United States. In Diabetes, 2012
These studies delineate a novel pathway that links hormonal and circadian signals to gluconeogenesis and glucose homeostasis.
Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization.
GeneRIF
Walker et al., Edinburgh, United Kingdom. In Diabetes, 2012
Reduced intra-adipose glucocorticoid regeneration by 11beta-HSD1 is a novel mechanism that contributes to the metabolic efficacy of salicylates.
BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice.
GeneRIF
Ding et al., Nanjing, China. In Plos One, 2011
11beta-HSD1 may be a very promising therapeutic target for obesity and associated disease.
Hyperglycemia induces the variations of 11β-hydroxysteroid dehydrogenase type 1 and peroxisome proliferator-activated receptor-γ expression in hippocampus and hypothalamus of diabetic rats.
GeneRIF
Chen et al., Beijing, China. In Exp Diabetes Res, 2011
Hyperglycemia induces the variations of 11beta-hydroxysteroid dehydrogenase type 1 and peroxisome proliferator-activated receptor-gamma expression in hippocampus and hypothalamus of diabetic rats
11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes.
Review
Tomlinson et al., Birmingham, United Kingdom. In Expert Opin Investig Drugs, 2010
AREAS COVERED IN THIS REVIEW: The endoluminal enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyzes glucocorticoid activation in key metabolic tissues including skeletal muscle, liver and adipose tissue, and is strongly implicated in the pathogenesis of obesity, type 2 diabetes and the metabolic syndrome.
INCB-13739, an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for the treatment of type 2 diabetes.
Review
Tiwari, Bengaluru, India. In Idrugs, 2010
INCB-13739, being developed by Incyte Corp, is a novel, first-in-class 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor for the potential treatment of metabolic disorders, including type 2 diabetes mellitus (T2DM) and obesity.
The glucocorticoid-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 has broad substrate specificity: Physiological and toxicological considerations.
Review
Nashev et al., Basel, Switzerland. In J Steroid Biochem Mol Biol, 2010
The primary function of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is to catalyze the conversion of inactive to active glucocorticoid hormones and to modulate local glucocorticoid-dependent gene expression.
11beta-Hydroxysteroid dehydrogenase type 1 is an important regulator at the interface of obesity and inflammation.
Review
Maser et al., Kiel, Germany. In J Steroid Biochem Mol Biol, 2010
The current obesity epidemic, however, is not characterized by increased plasma cortisol concentrations, but instead comes along with chronic low-grade inflammation in adipose tissue and concomitant increased levels of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1, gene HSD11B1), a parameter known to cause obesity in a mouse model.
11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
Review
Impact
Stewart et al., Birmingham, United Kingdom. In Endocr Rev, 2004
11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) interconverts inactive cortisone and active cortisol.
Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.
Impact
Stewart et al., Birmingham, United Kingdom. In Nat Genet, 2003
This suggests a defect in the gene HSD11B1 encoding 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), a primary regulator of tissue-specific glucocorticoid bioavailability.
11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess.
Review
Impact
Agarwal et al., Dallas, United States. In Endocr Rev, 1997
Whereas aldosterone is normally a much stronger mineralocorticoid than cortisol in vivo, mineralocorticoid receptors have identical in vitro affinities for these hormones.
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