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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Aldehyde dehydrogenase 1 family, member L1

10-formyltetrahydrofolate dehydrogenase, ALDH1L1, N-10-formyltetrahydrofolate dehydrogenase
Top mentioned proteins: ACID, Glial Fibrillary Acidic Protein, CAN, V1a, SET
Papers on 10-formyltetrahydrofolate dehydrogenase
Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia.
New
Kalaria et al., Newcastle upon Tyne, United Kingdom. In Brain, Jan 2016
Other markers such as aldehyde dehydrogenase 1 family, member L1 (ALDH1L1) showed cytoplasmic disintegration of the astrocytes.
Generation of GFAP::GFP astrocyte reporter lines from human adult fibroblast-derived iPS cells using zinc-finger nuclease technology.
New
Rothstein et al., Helsinki, Finland. In Glia, Jan 2016
Astrocyte populations were enriched using Fluorescence Activated Cell Sorting (FACS) and after enrichment more than 99% of iPS astrocytes expressed mature astrocyte markers including GFAP, S100β, NFIA and ALDH1L1.
Transcriptome profiling of sleeping, waking, and sleep deprived adult heterozygous Aldh1L1 - eGFP-L10a mice.
New
Cirelli et al., Madison, United States. In Genom Data, Dec 2015
We used bacterial artificial chromosome (BAC) transgenic mice expressing eGFP tagged ribosomal protein L10a under the promoter of the Aldh1L1 gene, a highly expressed astrocytic gene.
Heterogeneity of Notch signaling in astrocytes and the effects of GFAP and vimentin deficiency.
New
Pekny et al., Göteborg, Sweden. In J Neurochem, Oct 2015
Here, we used real-time quantitative PCR to analyze gene expression in individual mouse astrocytes in primary cultures and in GFAP(POS) or Aldh1L1(POS) astrocytes freshly isolated from uninjured, contralesional and lesioned hippocampus 4 days after entorhinal cortex lesion.
Deimination level and peptidyl arginine deiminase 2 expression are elevated in astrocytes with increased incubation temperature.
New
Serra et al., Córdoba, Argentina. In J Neurosci Res, Sep 2015
We found increased expression of glial fibrillary acidic protein, ALDH1L1, and J1-31, resulting from increased incubation temperature and increased expression of TSP1, S100β, and AQP4, resulting from decreased incubation temperature vs. optimal temperature, suggesting activation of different biochemical pathways in astrocytes associated with different incubation temperatures.
N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes.
New
Hurley et al., Indianapolis, United States. In Chem Biol Interact, Jul 2015
We sought to determine the selectivity of DEAB toward ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH1L1, ALDH2, ALDH3A1, ALDH4A1 and ALDH5A1 isoenzymes and determine the mechanism by which DEAB exerts its inhibitory action.
Aldehyde dehydrogenase homologous folate enzymes: Evolutionary switch between cytoplasmic and mitochondrial localization.
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Krupenko et al., Kannapolis, United States. In Chem Biol Interact, Jul 2015
There is a significant degree of sequence similarity between the two enzymes due to an apparent origin of the gene for the mitochondrial enzyme (ALDH1L2) from the duplication of the gene for the cytosolic enzyme (ALDH1L1).
Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes.
New
Perkins et al., San Diego, United States. In Glia, May 2015
In BAC ALDH1L1 eGFP or Thy1-CFP transgenic mice, NMDA treatment induced axon loss as well as hypertrophic morphology and mitochondrial fission in astrocytes of the glial lamina.
Structures of the hydrolase domain of zebrafish 10-formyltetrahydrofolate dehydrogenase and its complexes reveal a complete set of key residues for hydrolysis and product inhibition.
New
Chen et al., Taiwan. In Acta Crystallogr D Biol Crystallogr, Apr 2015
10-Formyltetrahydrofolate dehydrogenase (FDH), which is composed of a small N-terminal domain (Nt-FDH) and a large C-terminal domain, is an abundant folate enzyme in the liver and converts 10-formyltetrahydrofolate (10-FTHF) to tetrahydrofolate (THF) and CO2.
Distinct prognostic values of ALDH1 isoenzymes in breast cancer.
New
Bai et al., Guangzhou, China. In Tumour Biol, Apr 2015
ALDH1A2 and ALDH1L1 mRNA high expressions were found to be correlated to better OS for all BC patients.
Involvement of aldehyde dehydrogenase 1A2 in the regulation of cancer stem cell properties in neuroblastoma.
New
Nishimura et al., Kōbe, Japan. In Int J Oncol, Mar 2015
While ALDH1A2, ALDH1L1 and ALDH3B2 expression was consistently induced in spheres and associated with the sphere and colony formation, only ALDH1A2 expression was significantly correlated with the poor prognosis of neuroblastoma patients.
Global transcriptome analysis of peripheral blood identifies the most significantly down-regulated genes associated with metabolism regulation in Klinefelter syndrome.
Liu et al., Beijing, China. In Mol Reprod Dev, 2015
Genes associated with metabolism regulation and encoding liver fatty acid-binding protein (FABP1), aldehyde dehydrogenase 1 family member L1 (ALDH1L1), and vitronectin (VTN) were the most-significantly down-regulated in KS, as confirmed by quantitative reverse transcription PCR.
Understanding the role of dicer in astrocyte development.
Fu et al., San Francisco, United States. In Plos One, 2014
In this study, we use Aldh1l1-EGFP transgene, a marker of astrocytes, to characterize mouse models with conditional Dicer1 ablation (via either human or mouse GFAP-Cre).
Distinct prognostic values and potential drug targets of ALDH1 isoenzymes in non-small-cell lung cancer.
Xu et al., Shanghai, China. In Drug Des Devel Ther, 2014
High expression of both ALDH1A3 and ALDH1L1 mRNA was not found to be correlated to OS in all NSCLC patients.
FDH: an aldehyde dehydrogenase fusion enzyme in folate metabolism.
Review
Krupenko, Charleston, United States. In Chem Biol Interact, 2009
FDH (10-formyltetrahydrofolate dehydrogenase, Aldh1L1, EC 1.5.1.6)
The folate metabolic enzyme ALDH1L1 is restricted to the midline of the early CNS, suggesting a role in human neural tube defects.
GeneRIF
Heintz et al., New York City, United States. In J Comp Neurol, 2007
These data provide the first evidence for localized differences in folate metabolism within the early neural tube and suggest that folate might modulate proliferation via effects on midline Aldh1l1(+) cells.
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