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Phosphoinositide-3-kinase, catalytic, gamma polypeptide

1-Phosphatidylinositol 3-Kinase, PI3-kinase
This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Akt, V1a, PI3K, CAN, Insulin
Papers on 1-Phosphatidylinositol 3-Kinase
B7-H3 increases thymidylate synthase expression via the PI3k-Akt pathway.
New
Hua et al., Wuxi, China. In Tumour Biol, Feb 2016
Further investigation has revealed elevated expression of thymidylate synthase (TS) and upregulation of the PI3-kinase (PI3K)/Akt pathway in B7-H3 overexpressing cells.
Gastrin Decreases Na+, K+-ATPase Activity via a PI3 Kinase- and PKC-Dependent Pathway in Human Renal Proximal Tubule Cells.
New
Jose et al., Washington, United Kingdom. In Am J Physiol Endocrinol Metab, Feb 2016
Recently we reported that gastrin induces NHE3 phosphorylation and internalization via phosphatidylinositol 3-kinase (PI3 kinase) and PKCα.
Inside-Out Signaling Pathways from Nuclear Reactive Oxygen Species Control Pulmonary Innate Immunity.
New
Brasier et al., Galveston, United States. In J Innate Immun, Feb 2016
In parallel, nuclear ROS are detected by ataxia telangiectasia mutated (ATM), a PI3 kinase activated by ROS, triggering its nuclear export.
Up-regulation of the Ang II /AT1 receptor may compensate for the loss of gastric antrum ICC via the PI3k/Akt signaling pathway in STZ-induced diabetic mice.
New
Xu et al., Shanghai, China. In Mol Cell Endocrinol, Feb 2016
These effects were reduced by specific inhibitors ZD7155 (an AT1R antagonist) and LY294002 (a PI3-kinase inhibitor).
Targeted therapies for CLL: Practical issues with the changing treatment paradigm.
Review
New
O'Brien et al., Houston, United States. In Blood Rev, Jan 2016
These include B-cell receptor (BCR) inhibitors such as Bruton tyrosine kinase (BTK) inhibitors, PI3 kinase inhibitors, and Syk inhibitors, novel anti-CD20 monoclonal antibodies such as ofatumumab and obinutuzumab, and Bcl-2 antagonists such as venetoclax (ABT-199).
Rumex acetosa L. induces vasorelaxation in rat aorta via activation of PI3-kinase/Akt- AND Ca(2+)-eNOS-NO signaling in endothelial cells.
New
Jin et al., China. In J Physiol Pharmacol, Dec 2015
Inhibition of PI3-kinase/Akt signaling pathway markedly reduced the ERA-induced vasorelaxation.
Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells.
New
Impact
Batista et al., Boston, United States. In Immunity, Nov 2015
Furthermore, in the absence of WIP, several receptors, namely the BCR, BAFFR, CXCR4, CXCR5, CD40, and TLR4, were impaired in promoting CD19 co-receptor activation and subsequent PI3 kinase (PI3K) signaling.
PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development.
New
Impact
Kopf et al., Zürich, Switzerland. In Immunity, Nov 2015
Development of dendritic cells (DCs) commences in the bone marrow, from where pre-DCs migrate to peripheral organs to differentiate into mature DCs in situ.
PTEN inhibition and axon regeneration and neural repair.
Review
New
Li et al., Philadelphia, United States. In Neural Regen Res, Sep 2015
Among them, PI3 kinase/Akt pathway is important for controlling axon elongation.
Vps34 and PLD1 take center stage in nutrient signaling: their dual roles in regulating autophagy.
Review
Yoon, Inch'ŏn, South Korea. In Cell Commun Signal, 2014
The class III PI3 kinase Vps34 and its product phosphatidylinositol-3-phosphate (PI(3)P) play a critical role in this process, and enable the amino acid-mediated activation of mammalian target of rapamycin (mTOR), a suppressor of autophagy.
The twisted survivin connection to angiogenesis.
Review
Quest et al., Santiago, Chile. In Mol Cancer, 2014
Mechanistically, we propose the existence of a positive feed-back loop involving PI3-kinase/Akt activation and enhanced β-Catenin-TCF/LEF-dependent VEGF expression followed by secretion.
Glucocorticoid-Induced Osteoporosis.
Review
Tuckermann et al., Los Angeles, United States. In Adv Exp Med Biol, 2014
They also inhibit downstream kinases, including PI3-kinase and the MAP kinase ERK, the latter attributable in part to direct transcriptional stimulation of MAP kinase phosphatase 1.
Activation of vascular endothelial growth factor receptor-3 in macrophages restrains TLR4-NF-κB signaling and protects against endotoxin shock.
Impact
Wang et al., Shanghai, China. In Immunity, 2014
VEGFR-3 restrained TLR4-NF-κB activation by regulating the PI3-kinase-Akt signaling pathway and SOCS1 expression.
Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance.
Impact
Downward et al., London, United Kingdom. In Cancer Cell, 2013
However, it is unknown whether interaction of RAS with PI3-kinase is required in established tumors.
Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1.
Impact
Karsenty et al., New York City, United States. In Cell Metab, 2013
Adiponectin fulfills these functions, independently of its known receptors and signaling pathways, by decreasing FoxO1 activity in a PI3-kinase-dependent manner.
GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kγ activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production.
GeneRIF
Sabe et al., Kumamoto, Japan. In Mol Biol Cell, 2012
a novel mechanism that links PI3Kgamma activity with chemotaxis and superoxide production in G-protein coupled receptor signaling.
Variation in a locus linked to platelet aggregation phenotype predicts intraparenchymal hemorrhagic volume.
GeneRIF
Connolly et al., New York City, United States. In Neurol Res, 2012
findings suggest that PIK3CG function impacts the severity of the intraparenchymal bleed in patients with intracerebral hemorrhage
The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ.
GeneRIF
Nürnberg et al., Tübingen, Germany. In Biochem J, 2012
A novel regulatory role of p101 in the activation of PI3Kgamma.
Interaction of Ras with p110γ is required for thymic β-selection in the mouse.
GeneRIF
Turner et al., Cambridge, United Kingdom. In J Immunol, 2011
Ras-p110gamma interaction is necessary for efficient beta-selection-promoted proliferation but is dispensable for the survival or differentiation of thymocytes.
PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance.
GeneRIF
Solinas et al., Fribourg, Switzerland. In Proc Natl Acad Sci U S A, 2011
protection from insulin resistance, metabolic inflammation, and fatty liver in mice lacking functional PI3Kgamma is largely consequent to their leaner phenotype
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