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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Phospholipase A2, group VII

1-Alkyl-2-acetylglycerophosphocholine Esterase, LIS1, platelet-activating factor acetylhydrolase, PAF-AH, PAF acetylhydrolase
The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009] (from NCBI)
Top mentioned proteins: PAF, HAD, CAN, ACID, HDL
Papers using 1-Alkyl-2-acetylglycerophosphocholine Esterase antibodies
NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores
Vallee Richard B. et al., In The Journal of Cell Biology, 2002
... (BD Biosciences), polyclonal anti-LIS1 (Santa Cruz Biotechnology, Inc.), monoclonal anti-LIS1 (provided ...
The isolation of novel inhibitory polypeptides of protein phosphatase 1 from bovine thymus nuclei
Nekhai Sergei et al., In Retrovirology, 1991
... Rabbit polyclonal LIS1 antibodies were purchased from Novus Biologicals.
Papers on 1-Alkyl-2-acetylglycerophosphocholine Esterase
Activity and distribution of plasma platelet-activating factor acetylhydrolase in women with gestational diabetes mellitus and their neonates.
Fan et al., Chengdu, China. In Diabetes Metab Res Rev, Feb 2016
BACKGROUND: Abnormal activity and distribution of plasma platelet-activating factor acetylhydrolase (PAF-AH) are associated with chronic inflammatory status.
The onset of lipid peroxidation in rheumatoid arthritis: consequences and monitoring.
Skrzydlewska et al., Białystok, Poland. In Free Radic Res, Feb 2016
Cytosolic phospholipase A2 (cPLA2), platelet-activating factor acetylhydrolase (PAF-AH) and glutathione peroxidase (GSH-Px) activities and vitamin E levels were also determined.
Increased susceptibility to bladder inflammation in smokers: targeting the PAF-PAF receptor interaction to manage inflammatory cell recruitment.
McHowat et al., Saint Louis, United States. In Physiol Rep, Dec 2015
In response to cigarette smoke extract (CSE) incubation, bladder endothelial cells from human or mouse displayed increased PAF accumulation, decreased PAF-AH activity, and increased inflammatory cell adherence.
[Lp-PLA2, a biomarker of vascular inflammation and vulnerability of atherosclerosis plaques].
Bonnefont-Rousselot, Paris, France. In Ann Pharm Fr, Nov 2015
Among the emerging biomarkers of atherogenesis, the lipoprotein-associated phospholipase A2 (Lp-PLA2), formerly known as PAF-acetylhydrolase (McIntyre et al., 2009), hydrolyses the oxidized short chain phospholipids of low-density lipoproteins (LDL), thereby releasing pro-inflammatory mediators (lysophospholipids and oxidized fatty acids).
Cytoplasmic dynein and early endosome transport.
Zhang et al., Bethesda, United States. In Cell Mol Life Sci, Sep 2015
Early endosomes represent a major cargo of dynein in filamentous fungi, and dynein regulators such as LIS1 and the dynactin complex are both required for early endosome movement.
Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2014.
Leung et al., New York City, United States. In J Allergy Clin Immunol, Feb 2015
Studies have also provided insights into the prevalence and characteristics of anaphylaxis and insect venom allergy, such as suggesting that baseline platelet-activating factor acetylhydrolase activity levels are related to the severity of reactions.
Diverse Functions of Plasma PAF-AH in Tumorigenesis.
Stafforini, Salt Lake City, United States. In Enzymes, 2014
Biochemical and other properties of this enzyme were discussed in detail in chapter "Plasma PAF-AH (PLA2G7): Biochemical Properties, Association with LDLs and HDLs, and Regulation of Expression" by Stafforini and in other chapters.
Naturally Occurring Missense Mutation in Plasma PAF-AH Among the Japanese Population.
Karasawa, Tokyo, Japan. In Enzymes, 2014
A single nucleotide polymorphism in the plasma PAF-AH enzyme, i.e., G994T, which causes the substitution of Val at amino acid 279 with Phe (V279F), has been found in the Japanese population.
Genotype-phenotype correlation in neuronal migration disorders and cortical dysplasias.
Kato, Yamagata, Japan. In Front Neurosci, 2014
Mutations of many genes are involved in neuronal migration disorders, such as LIS1 and DCX in classical lissencephaly spectrum, TUBA1A in microlissencephaly with agenesis of the corpus callosum, and RELN and VLDLR in lissencephaly with cerebellar hypoplasia.
Somatic mutations in cerebral cortical malformations.
Walsh et al., Boston, United States. In N Engl J Med, 2014
Mutations were somatic in 8 of the 27 (30%), predominantly in persons with the double-cortex syndrome (in whom we found mutations in DCX and LIS1), persons with periventricular nodular heterotopia (FLNA), and persons with pachygyria (TUBB2B).
Cardiac risk factors: biomarkers and genetic tests to determine cardiovascular risk.
Eaton et al., Providence, United States. In Fp Essent, 2014
Another biomarker is platelet-activating factor acetylhydrolase (Lp-PLA2).
LIS1 clamps dynein to the microtubule.
Surrey et al., In Cell, 2012
By using a combination of approaches including single-molecule biophysics and electron microscopy, Huang et al. in this issue uncover the regulatory mechanism by which LIS1 controls the activity of cytoplasmic dynein.
Clinical utility of lipoprotein-associated phospholipase A₂ for cardiovascular disease prediction in a multiethnic cohort of women.
Ridker et al., Boston, United States. In Clin Chem, 2012
In the WHI-OS Lp-PLA2 mass, but not activity, was independently associated with CVD. However, model fit did not significantly improve with Lp-PLA2 mass, and assay calibration remains a clinical concern
Regulation of dynein localization and centrosome positioning by Lis-1 and asunder during Drosophila spermatogenesis.
Lee et al., Nashville, United States. In Development, 2012
present a model in which Lis-1 and asun cooperate to regulate dynein localization and centrosome positioning during spermatogenesis
Apo E4 and lipoprotein-associated phospholipase A2 synergistically increase cardiovascular risk.
Berglund et al., İstanbul, Turkey. In Atherosclerosis, 2012
The presence of the apo E4 isoform was associated with a higher level of Lp-PLA(2) index, a marker of vascular inflammation, synergistically increasing cardiovascular risk.
Evidence supporting a key role of Lp-PLA2-generated lysophosphatidylcholine in human atherosclerotic plaque inflammation.
Nilsson et al., Malmö, Sweden. In Arterioscler Thromb Vasc Biol, 2012
The associations among Lp-PLA2, lysophosphatidylcholine, and proinflammatory cytokines in human plaques suggest that lysoPCs play a key role in plaque inflammation and vulnerability.
Mapping of clinical and expression quantitative trait loci in a sex-dependent effect of host susceptibility to mouse-adapted influenza H3N2/HK/1/68.
Vidal et al., Montréal, Canada. In J Immunol, 2012
Pla2g7 and Tnfrsf21 have been identified as genetic susceptibility to influenza genes in mice.
LIS1 and NudE induce a persistent dynein force-producing state.
Gross et al., New York City, United States. In Cell, 2010
LIS1, NudE, and NudEL are dynein interactors initially implicated in brain developmental disease but now known to be required in cell migration, nuclear, centrosomal, and microtubule transport, mitosis, and growth cone motility.
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.
Hirotsune et al., Ōsaka, Japan. In Nat Med, 2009
Inhibition of calpain increases Lis1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.
Increased LIS1 expression affects human and mouse brain development.
Reiner et al., Houston, United States. In Nat Genet, 2009
An increase in LIS1 expression in the developing brain results in brain abnormalities in mice and humans.
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