[Lp-PLA2, a biomarker of vascular inflammation and vulnerability of atherosclerosis plaques].
Paris, France. In Ann Pharm Fr, Nov 2015
Among the emerging biomarkers of atherogenesis, the lipoprotein-associated phospholipase A2 (Lp-PLA2), formerly known as PAF-acetylhydrolase (McIntyre et al., 2009), hydrolyses the oxidized short chain phospholipids of low-density lipoproteins (LDL), thereby releasing pro-inflammatory mediators (lysophospholipids and oxidized fatty acids).
Cytoplasmic dynein and early endosome transport.
Bethesda, United States. In Cell Mol Life Sci, Sep 2015
Early endosomes represent a major cargo of dynein in filamentous fungi, and dynein regulators such as LIS1 and the dynactin complex are both required for early endosome movement.
Diverse Functions of Plasma PAF-AH in Tumorigenesis.
Salt Lake City, United States. In Enzymes, 2014
Biochemical and other properties of this enzyme were discussed in detail in chapter "Plasma PAF-AH (PLA2G7): Biochemical Properties, Association with LDLs and HDLs, and Regulation of Expression" by Stafforini and in other chapters.
Somatic mutations in cerebral cortical malformations.
Boston, United States. In N Engl J Med, 2014
Mutations were somatic in 8 of the 27 (30%), predominantly in persons with the double-cortex syndrome (in whom we found mutations in DCX and LIS1), persons with periventricular nodular heterotopia (FLNA), and persons with pachygyria (TUBB2B).
LIS1 clamps dynein to the microtubule.
In Cell, 2012
By using a combination of approaches including single-molecule biophysics and electron microscopy, Huang et al. in this issue uncover the regulatory mechanism by which LIS1 controls the activity of cytoplasmic dynein.
LIS1 and NudE induce a persistent dynein force-producing state.
New York City, United States. In Cell, 2010
LIS1, NudE, and NudEL are dynein interactors initially implicated in brain developmental disease but now known to be required in cell migration, nuclear, centrosomal, and microtubule transport, mitosis, and growth cone motility.